EIF2A_CAEEL
ID EIF2A_CAEEL Reviewed; 570 AA.
AC Q19052; Q95ZW6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Eukaryotic translation initiation factor 2A;
DE Short=eIF-2A;
GN Name=eif-2A {ECO:0000312|WormBase:E04D5.1a};
GN ORFNames=E04D5.1 {ECO:0000312|WormBase:E04D5.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000250|UniProtKB:Q9BY44}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:E04D5.1a};
CC IsoId=Q19052-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:E04D5.1b};
CC IsoId=Q19052-2; Sequence=VSP_024979, VSP_024980;
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284602; CAA91279.2; -; Genomic_DNA.
DR EMBL; BX284602; CAC42280.2; -; Genomic_DNA.
DR PIR; T20450; T20450.
DR RefSeq; NP_496239.2; NM_063838.4. [Q19052-1]
DR RefSeq; NP_496240.2; NM_063839.4.
DR AlphaFoldDB; Q19052; -.
DR SMR; Q19052; -.
DR BioGRID; 39924; 16.
DR STRING; 6239.E04D5.1a.2; -.
DR iPTMnet; Q19052; -.
DR EPD; Q19052; -.
DR PaxDb; Q19052; -.
DR PeptideAtlas; Q19052; -.
DR EnsemblMetazoa; E04D5.1a.1; E04D5.1a.1; WBGene00008480. [Q19052-1]
DR EnsemblMetazoa; E04D5.1b.1; E04D5.1b.1; WBGene00008480. [Q19052-2]
DR GeneID; 174606; -.
DR KEGG; cel:CELE_E04D5.1; -.
DR UCSC; E04D5.1a.1; c. elegans. [Q19052-1]
DR CTD; 174606; -.
DR WormBase; E04D5.1a; CE37820; WBGene00008480; eif-2A. [Q19052-1]
DR WormBase; E04D5.1b; CE37821; WBGene00008480; eif-2A. [Q19052-2]
DR eggNOG; KOG2315; Eukaryota.
DR GeneTree; ENSGT00730000111053; -.
DR HOGENOM; CLU_013809_1_0_1; -.
DR InParanoid; Q19052; -.
DR OMA; LITWQRP; -.
DR OrthoDB; 464990at2759; -.
DR PhylomeDB; Q19052; -.
DR PRO; PR:Q19052; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00008480; Expressed in adult organism and 4 other tissues.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; PTHR13227; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Coiled coil; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; Translation regulation; WD repeat.
FT CHAIN 1..570
FT /note="Eukaryotic translation initiation factor 2A"
FT /id="PRO_0000286081"
FT REPEAT 274..316
FT /note="WD 1"
FT REPEAT 318..358
FT /note="WD 2"
FT REGION 468..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 519..541
FT /evidence="ECO:0000255"
FT COMPBIAS 487..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104..177
FT /note="TAENQKPEPNVRVYSLADGKHVSTFSAPKEASWEPQFSDDESLAARMVGSEV
FT FFYTNMSFDRYDHKLVEKGATN -> RTKSQNQMCESTVLRMESTYQRSQLQKKHRGSL
FT SFRMMSRWLQEWLAVKSSFIQTCLSTVTTTSLSRRVRPTSH (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_024979"
FT VAR_SEQ 178..570
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_024980"
SQ SEQUENCE 570 AA; 64020 MW; 602708105C2E2A0F CRC64;
MGDNLVYAVR SSEGFYLKRG LGKDAVTVFE QNKTSRDVAC NVFAYSNNGQ LFAYCDNQVT
RVFEIATNKE ILCVELKRTR KILFSPKDNF LLTFEPWAVY GPKTAENQKP EPNVRVYSLA
DGKHVSTFSA PKEASWEPQF SDDESLAARM VGSEVFFYTN MSFDRYDHKL VEKGATNFAL
SPGPAPNHVA VYVPAVGSTP ARVRVHRVSE SFPVVGNRTF FKSDKAVMTW NQRGQSLLIL
ASVEVDKTNQ SYYGEQSLYL INIQSGESVV VPLEKKGPIY AAKWNPNGRE FAVCYGYMPA
KVTFYNPRGV PIFDTIEGPR NDVFYNAFGN IVLICGFGNI AKGKMEFWDV ETKKEIISIE
VPNTTLFDWA PDGQHFVTCT TAPRLRIDNS YRFWHYTGRM LAETHFESPK ELWEVRWRPM
TGYNKFAIKE LTKTDKMAAG LPIRKKDASH PLNNVPAGAV RQAGAYIPPH LRKPLGGGGS
AGPPSAAAPT PGNQNQRPAQ PRANGNGNAP QPFRPQQSEQ ERKAFQLKKK VEEIKVLKQR
VANGDQLQPN QMEKIQRENE YLSELSKLTI
