ID   EIF2A_CHICK             Reviewed;         586 AA.
AC   Q5ZKC1;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Eukaryotic translation initiation factor 2A;
DE            Short=eIF-2A;
GN   Name=EIF2A; ORFNames=RCJMB04_11n11;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC       number of specific mRNAs. Acts by directing the binding of methionyl-
CC       tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC       binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC       whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC       GTP-dependent manner. {ECO:0000250|UniProtKB:Q9BY44}.
CC   -!- SIMILARITY: Belongs to the WD repeat EIF2A family. {ECO:0000305}.
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DR   EMBL; AJ720163; CAG31822.1; -; mRNA.
DR   RefSeq; NP_001026494.1; NM_001031323.2.
DR   AlphaFoldDB; Q5ZKC1; -.
DR   SMR; Q5ZKC1; -.
DR   BioGRID; 685344; 1.
DR   STRING; 9031.ENSGALP00000016918; -.
DR   PaxDb; Q5ZKC1; -.
DR   PRIDE; Q5ZKC1; -.
DR   GeneID; 425042; -.
DR   KEGG; gga:425042; -.
DR   CTD; 83939; -.
DR   VEuPathDB; HostDB:geneid_425042; -.
DR   eggNOG; KOG2315; Eukaryota.
DR   InParanoid; Q5ZKC1; -.
DR   OrthoDB; 464990at2759; -.
DR   PhylomeDB; Q5ZKC1; -.
DR   PRO; PR:Q5ZKC1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005850; C:eukaryotic translation initiation factor 2 complex; ISS:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0000049; F:tRNA binding; ISS:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; ISS:UniProtKB.
DR   GO; GO:0042255; P:ribosome assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011387; TIF2A.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13227; PTHR13227; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   PIRSF; PIRSF017222; eIF2A; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; Translation regulation; WD repeat.
FT   CHAIN           1..586
FT                   /note="Eukaryotic translation initiation factor 2A"
FT                   /id="PRO_0000286078"
FT   REPEAT          23..63
FT                   /note="WD 1"
FT   REPEAT          125..163
FT                   /note="WD 2"
FT   REPEAT          356..401
FT                   /note="WD 3"
FT   REGION          434..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          532..583
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        469..483
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        504..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   586 AA;  64504 MW;  A4A1DD61FA8A2E4D CRC64;
     MAPPAPLLAV RGSEGLFMVN GPPSFTESAV FQRDSGRNCK AVAFSKDGSL FAWCNGEKVN
     IVNVTSAGLL RSFDLPKVVC LEFSPKNNIL ATWQAYSAAK DGTAGAPNLQ LYDVKTGKCL
     KSFIQKKMQN WCPCWADDES ICARNVNNEV HFFENNNFNT IANKLHLQKV NDFVLSPGAQ
     PTKVAVYVPG SKGAPSFVRL YQYPNFGGPQ SALANKSFFK ADKVTMLWNK KATAVLVIAS
     TDVDKTGASY YGEQTLHYIA TNGESAIVQL PKNGPIYDVV WNPNSVEFCA VYGFMPAKAT
     VFNLKCDPVF DFGTGPRNAA YYSPHGHILV LAGFGNLRGQ MEVWDVKNYK LISKPVASDS
     TYFAWCPDGE HIVTATCAPR LRVSNGYKIW HYTGSVLHNY EVPSNEEMWQ VSWQPFLDGV
     FPVKAVKYQA VPSELPSAEP KPAQAYRPPA LRNKPVTSSK LHEDEPPQNM KPQSGSSEKP
     LSKTALKNQK KHEPKKAAKQ EAKADCSQES TQSSASQNTP RSAVPVVTSG DPEIDKKIKN
     LKKKLKAIEQ LKEQAAAGKQ LEKNQLEKIQ KESALLQELE DLELGL