EIF2A_DANRE
ID EIF2A_DANRE Reviewed; 580 AA.
AC Q4QRJ7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Eukaryotic translation initiation factor 2A;
DE Short=eIF-2A;
GN Name=eif2a; ORFNames=zgc:110460;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000250|UniProtKB:Q9BY44}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family. {ECO:0000305}.
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DR EMBL; BC096815; AAH96815.1; -; mRNA.
DR RefSeq; NP_001020341.1; NM_001025170.2.
DR AlphaFoldDB; Q4QRJ7; -.
DR SMR; Q4QRJ7; -.
DR STRING; 7955.ENSDARP00000068657; -.
DR PaxDb; Q4QRJ7; -.
DR PRIDE; Q4QRJ7; -.
DR DNASU; 573991; -.
DR GeneID; 573991; -.
DR KEGG; dre:573991; -.
DR CTD; 83939; -.
DR ZFIN; ZDB-GENE-050626-52; eif2a.
DR eggNOG; KOG2315; Eukaryota.
DR InParanoid; Q4QRJ7; -.
DR OrthoDB; 1194797at2759; -.
DR PhylomeDB; Q4QRJ7; -.
DR PRO; PR:Q4QRJ7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; PTHR13227; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; Translation regulation; WD repeat.
FT CHAIN 1..580
FT /note="Eukaryotic translation initiation factor 2A"
FT /id="PRO_0000286079"
FT REPEAT 21..62
FT /note="WD 1"
FT REPEAT 72..121
FT /note="WD 2"
FT REPEAT 270..311
FT /note="WD 3"
FT REPEAT 355..399
FT /note="WD 4"
FT REGION 435..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 481..578
FT /evidence="ECO:0000255"
SQ SEQUENCE 580 AA; 64225 MW; 3DA2937E27BC6A8F CRC64;
MAPPTPHLAV RGSDGTLLLH GPPNCQESSA FQRDDRQGRY MTFSNDGTLF AWCNGSQVTV
LKVPSGDLVK SFDLPKTTAL EFSPLNKVLA TWQQYTKTQD NPQGEANLQL WDLQTGACMK
AFYQKKMTGW CPSWADDESI SVRNVNNELH FFENNNFETI ANKLHLQKVS EFALSPGSQP
SKVAVYVPGS KGAPSFVRLY QYPNFGGPTC ALANKSFFKA DKVNMLWNKK ATAVLVTAST
EVDKTGASYY GEQTLHYVAT NGESAVVQLP KNGPIYDVSW SPNSTEFCVV YGFMPAKATV
FNNKCESVFD FGTGPRNAAF YSPQGHILVL AGFGNLRGQM EVWDVKKYKQ VSKPQAEDTT
HFSWCPDGEH IVTATCSPRL RASNGYKIWH YTGTVLYKHE TPSGKELWEV LWQPFPAGVF
PERAVKYQAL PSELGSTEAK PAQAYRPPAL RNKPQTASSK LHEEEPPQNM KPGAAGEKQP
SKAALKNQKR REAKKAAKQE NKPDEAPPPA ADPAPVSHVT SSCGDPETDK KIKNLKKKLK
AIDELKEQQA AGKVMQKNQL EKMQKEAQLL KELEDLELGL