ID   EIF2A_XENLA             Reviewed;         582 AA.
AC   Q7ZY11;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Eukaryotic translation initiation factor 2A;
DE            Short=eIF-2A;
GN   Name=eif2a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC       number of specific mRNAs. Acts by directing the binding of methionyl-
CC       tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC       binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC       whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC       GTP-dependent manner. {ECO:0000250|UniProtKB:Q9BY44}.
CC   -!- SIMILARITY: Belongs to the WD repeat EIF2A family. {ECO:0000305}.
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DR   EMBL; BC044026; AAH44026.1; -; mRNA.
DR   AlphaFoldDB; Q7ZY11; -.
DR   SMR; Q7ZY11; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR011387; TIF2A.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR13227; PTHR13227; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   PIRSF; PIRSF017222; eIF2A; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; Translation regulation; WD repeat.
FT   CHAIN           1..582
FT                   /note="Eukaryotic translation initiation factor 2A"
FT                   /id="PRO_0000286080"
FT   REPEAT          21..63
FT                   /note="WD 1"
FT   REPEAT          73..124
FT                   /note="WD 2"
FT   REPEAT          273..314
FT                   /note="WD 3"
FT   REPEAT          358..402
FT                   /note="WD 4"
FT   REGION          436..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          482..580
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        494..508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   582 AA;  64817 MW;  95B5238816763027 CRC64;
     MAPPMPLLSV RGSDGIQLVL GPPKFTDSET FQRDPSKNCK VSRFTKDGKL FGWCNGEVIN
     IVNCSDSKLL HTLDLPKVVS LEFSPKNTIL ATWQTYTTGK DGTAGTPNLQ LYDLKSGKIS
     NVKSFIQKKM ENWSPHWSDD ENICARNVNN EVHFFENNNF DTIANKLHLQ KVSDFELSPG
     EQPCKVAVYV PGSKGAPSFV RLYQYPNFSG PNSALANKSF FKADRVAMLW NSKATAVLVT
     ASTDVDKTGA SYYGEQTLHY IAVNGESAVV QLPKNGPIYD VTWNKNATEF CVVYGFMPAK
     ATVFNLKCDP IFDFGTGPRN AAFYSPQGHI LVLAGFGNLR GQMEVWDVKK YKLISKPTAS
     DATFFSWCPN GEHIITATCS PRLRVGNGYK IWHYTGTLLH KYDVPANSEL WQVSWQPFPD
     GVFPAKAIVY QAVPGDLPTQ ESKPAEAYRP PALRNKPVSS YKLHEDEPPQ SMMPQSTEKP
     MSKTALKNQK KREAKKAAKQ ESKMDEPAES DSTNVQNNTP VAVNTGDPET DKKIKNLKKK
     LKAIEQLKEL QSSGKTLEKN QIEKIQKEDI LLKELEDLEI GV