ID   EIF3A_AEDAE             Reviewed;        1133 AA.
AC   Q173M7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000255|HAMAP-Rule:MF_03000};
GN   Name=eIF3-S10 {ECO:0000255|HAMAP-Rule:MF_03000}; ORFNames=AAEL007078;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC       Rule:MF_03000}.
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DR   EMBL; CH477419; EAT41266.1; -; Genomic_DNA.
DR   RefSeq; XP_001658105.1; XM_001658055.1.
DR   AlphaFoldDB; Q173M7; -.
DR   SMR; Q173M7; -.
DR   STRING; 7159.AAEL007078-PA; -.
DR   PRIDE; Q173M7; -.
DR   GeneID; 5568726; -.
DR   KEGG; aag:5568726; -.
DR   VEuPathDB; VectorBase:AAEL007078; -.
DR   eggNOG; KOG2072; Eukaryota.
DR   HOGENOM; CLU_002096_1_1_1; -.
DR   InParanoid; Q173M7; -.
DR   OMA; VMYQTTA; -.
DR   OrthoDB; 967904at2759; -.
DR   PhylomeDB; Q173M7; -.
DR   Proteomes; UP000008820; Chromosome 1.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03000; eIF3a; 1.
DR   InterPro; IPR027512; EIF3A.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR14005; PTHR14005; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..1133
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   A"
FT                   /id="PRO_0000366331"
FT   DOMAIN          317..498
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          810..1133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          573..700
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT   COILED          784..886
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT   COMPBIAS        810..892
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        918..939
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        955..1085
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1093..1133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1133 AA;  133297 MW;  08609A617DF08B57 CRC64;
     MSRYMQRPEN ALKRANEFIE VGKPARALDT LQEVFRIKKW TYTWSESVIE PIMFKYLDLC
     VELKKSHIAK EGLFQYRNMF QLVNVGSLEN VIRGYLKMAE ERTEAAQQQS SQAILDIDDL
     DNLATPESIL MSAVCGEDAQ DRSDRTILLP WVKFLWESYC QCLELLKVNS HCENLYHDIA
     KMAFGFCLKY NRKMEFRKLC EKLRKHLEDI SKVSSQTANV SISKPETQQL NLDTRLNQLD
     CAIQMELWLE AYKAIEDIHG LMTLSKKTPM PKTMALYYQK LAMVFWKAGN QLFHAAALLK
     LFQLSRDMKK NVTQEEIQRM TSHVLIATLA IPLPSAHPEF DRFIETDKSP LEKAQKLAVL
     LGLQQPPTRA SLLKDVLRLN VLQLAAPQFQ NLYKWLEVEF DPLNLCERVQ NIIQEITVDE
     NNPYAQYTQA LQDVTLVRLV RQVSQVYQSI EFSRFLALAK FSTSFYLERI LVDCVRHNDM
     QITIDHRNHC VHFGTDLSES QREDHPDGPT LQSMPSEQVR SQLVNMSVVL HRAIATINPN
     RNKAERDRLR AQMVKSYEEN MVKEHQRILQ RQKKIEDRKE YIERVNLERE EKELRELEEV
     ARQHKLAEQR RLEQENEERE RKRYENEVQM IKERNMKEKI DQIKQTAAGQ KILKKFDEED
     IKKMNAEEIA AKEAEERQKE RKAHDNNLKS QEKKIDYFER AKRLEEIPLI EKYLEDKLVQ
     DKQFWEKQEA SRIEAAIAER KNAEAVQERL KRMQPDREIF WQKLKGERSN QFAEKLKAFN
     VALEEERKRR LTERVYERRE ERRQKWLREK EEERRRAEEE IRKQRQEEER IERERRAEER
     RIEDEKARLL EEKRRAREEE ATKKAEENRQ MQAKARERER EREADSWRDR RGGDAPAAAA
     QPNPAAQEAT KPESGWRTAG AREPRGEDAP KKDGVYQPRF RDVRGGGAGG AGGVERRADD
     QESNKWRHGG DDGGKDDRDG PRRMGGDRPP MRRGGDDRDD RGPIRRGGDD RDDRGPIRRG
     DRPPMRDGER GVGMRREGGD RERRDGGDRR DFGGNRDRRD DRGGPRRDDR GDRGGDRDSA
     WRRPAPRGGD DGGNWRTRQD QAKPKDDRRE ERPKEARNTG PDEDGWTDVK HHR