EIF3A_ANOGA
ID EIF3A_ANOGA Reviewed; 1124 AA.
AC Q7PGE8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 5.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=eIF3-S10 {ECO:0000255|HAMAP-Rule:MF_03000}; ORFNames=AGAP002340;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAAB01008859; EAA44958.5; -; Genomic_DNA.
DR RefSeq; XP_312628.5; XM_312628.5.
DR AlphaFoldDB; Q7PGE8; -.
DR SMR; Q7PGE8; -.
DR STRING; 7165.AGAP002340-PA; -.
DR PaxDb; Q7PGE8; -.
DR PRIDE; Q7PGE8; -.
DR GeneID; 1273627; -.
DR KEGG; aga:AgaP_AGAP002340; -.
DR CTD; 1273627; -.
DR VEuPathDB; VectorBase:AGAP002340; -.
DR eggNOG; KOG2072; Eukaryota.
DR HOGENOM; CLU_002096_2_1_1; -.
DR InParanoid; Q7PGE8; -.
DR OMA; VMYQTTA; -.
DR OrthoDB; 967904at2759; -.
DR PhylomeDB; Q7PGE8; -.
DR Proteomes; UP000007062; Chromosome 2R.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IBA:GO_Central.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0043614; C:multi-eIF complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; RNA-binding.
FT CHAIN 1..1124
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366332"
FT DOMAIN 317..498
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 812..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 96..124
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COMPBIAS 812..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..993
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1124 AA; 132343 MW; 6EA14E3F8FA0753A CRC64;
MSRYVQRPEN ALKRANEFID VGKKARALDT LQEVFRAKKW NYNWSESIIE PVMFKYLDLC
VELKKSHIAK EGLFQYRNMF QLVNVGSLEN VIRGYLKMAE ERTEQAQQQS SQATVDIDDL
DNLATPESIL MSAVCGEDAQ DRSDRTILLP WVKFLWESYC QCLELLKVNS HCETLYHDIA
RMAFQFCLKY NRKMEFRKLC EKLRKHLEDI CKVSSQTANV TISKPETQQL NLETRLHQLD
SAIQMELWLE AYKAIEDIHG LMQLSKKTPL PKTMALYYTK LAMVFWKAGN QLFHASALLK
LFQLSRDMKK NVTAEEIQRM TTHVLIATLA IPLPSAHPEF DRFIETDKSP MEKAQRLAFL
LGLQQSPSRA LLLKELIRLN VLQLAAPQFR HLYQLLEVEF DPLNLCDQVQ KIVDEIEADP
NSVYGQYIQA LKDVTLVRLV RQISQVYQTI EFPRLLELAK FADYHHLERI LVDCVRHNDM
QITIDHRNEC VHFGTDLSES QREDHPDGPT LQSMPSEQIR SQLVNMSVVL HRAIATINPN
RKKAERERLR AQMVHQYEEN ADKEHQRILQ RQKKIEDRKE YIERMNQERE EEELRLQEEQ
VRMQKLAEQR RLEAENEERE RKRHENELQM MKERNMKEKI EQIKQTATGQ KLLKKLDEEE
IRKLNTEEIA AREAEERLKE RKAHENNLKT QEKKIDYFER AKRLEEIPLI EKYLQDRSVQ
DKEFWEKQEA ARIEAAIAER KNAEACQERL KRMLPDRDVY WQQLKNERGN QFAEKLKQFN
QALEEERKRR LADRVVKRRE ERRMKWLKEK EEERRRIEEE LRKQKEEADR IERERRAEER
RIQDEKNRQL AEKQLAIAEE VERRRREELE QMKEADGRRE RRPAAGPAEP KPEESWRKGP
AAAAPANPAA DEPKKNVWQG SGRYGPGPRE RGGETGPKDK WRTGPEDHEK DGGGAGGMRR
GGDMRRGQDD RGPIRRGGGE ERGEREDRGP IRRGGGPGDA PAGTGTPRRD DRPGGWFNRD
RRDDRRDDRR DDRRDDRRGD DRGPRGGGER GNTWRRGPAD NADDNRRGPR DEGRQDTWRN
TRQDAAPKQK EDRPQREARP AQENVPPRSN AGPDEEGWTD VKHR
