EIF3A_CAEBR
ID EIF3A_CAEBR Reviewed; 1098 AA.
AC A8WM57;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Egg-laying defective protein 45 {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=egl-45 {ECO:0000255|HAMAP-Rule:MF_03000};
GN Synonyms=eif-3.A {ECO:0000255|HAMAP-Rule:MF_03000}; ORFNames=CBG00021;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; HE601477; CAP21561.1; -; Genomic_DNA.
DR RefSeq; XP_002642644.1; XM_002642598.1.
DR AlphaFoldDB; A8WM57; -.
DR SMR; A8WM57; -.
DR STRING; 6238.CBG00021; -.
DR EnsemblMetazoa; CBG00021.1; CBG00021.1; WBGene00023536.
DR GeneID; 8584638; -.
DR KEGG; cbr:CBG_00021; -.
DR CTD; 8584638; -.
DR WormBase; CBG00021; CBP13719; WBGene00023536; Cbr-egl-45.
DR eggNOG; KOG2072; Eukaryota.
DR HOGENOM; CLU_002096_2_2_1; -.
DR InParanoid; A8WM57; -.
DR OMA; WGSRDDR; -.
DR OrthoDB; 967904at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IBA:GO_Central.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0043614; C:multi-eIF complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0018991; P:oviposition; IEA:EnsemblMetazoa.
DR GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; RNA-binding.
FT CHAIN 1..1098
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366348"
FT DOMAIN 324..503
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 599..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 574..844
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COMPBIAS 805..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1055
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 127717 MW; 021A3F1CABEB5509 CRC64;
MAPNYFQKPE AALKRAEELI QVGKESDALD TLHDTIKARR HKQWTTVHEQ IMIKHMELCV
DLKKQHLAKD ALFQYKALTQ QINVKSLETV VEHFLKLAEQ RTEDAQKQSI EKVEEIGDLD
QGDVPERLLL AVVSGAAAQD RMDRTVLAPW LRFLWDSYRN CLELLRNNAQ VEQLYHTISR
HSFSFCLRYQ RRTEFRKLCD LLRMHLNQIQ KHQYAPNVNS FRVKLTSPES LTLMQDTRLV
QLDTAIQMEL WQEAYKSAED VHGMMQLSKD KDKRTVKPSS YVNYYDKLAL VFWKAGNRLF
HAAALLQKFI IYKDMKKSFT QEEAQEQATR VLLATLSIPE GSDLPSDLSR NLDIEEQHVA
NMRLLSNLLR LPIAPTKVGI LKEAARIGVP EAAGQVAKDL FKLLESNFSP LRVAKDVQSV
LDTITRPDHL QYVESLQAVA AVKALKQVSV IYEAISWERI RKIIPFYHDL ALERLVVEAS
KHRIVKAQLD HRADCVRFGS SDATLAGGVD EYDNNEGFTG DDTQLGVEGV RNHLEAMYTR
LRVLVEGLDS EKRRKEIVKK IENHVTSYEK NRVTEIERIH RRKKMLENYK ENWERVKAEK
AATAATEQAK REEAARAEEM KRLDEQNKES ERKRKQAEQE EIQKKIKRDQ LHKMQQNVIY
QAIIKEKGLE QFRDMDPEQV LREQRERLDK ERAETQRRLQ QQEKKFDHHI RALHLEEMNE
RRAVMHMRLN EAPRLHEEYE NKRIEKEIAA HENHVKLWSM WDQVREATLD WVETVKVENQ
ENLEKKISDW EVKLEAVRNS RLAERAEKRK KERKEAAMQA KIAEERKRRE EEERARQAVI
DSQRRPHGER GQRREMENSA AMQDSDWRRN APPRDSMPQR EPRPMRDGPP REPFREMPSS
KADTDSSWRS SAQPTRKPDD RRSDDFRRDD GPRRSDDHRR NDEFRRSDDF RRNDDFRRDG
PPRPMSKADT DQKWERGAVT KTVVSPPKTE NQPAPAAEAP KADGPRRFIP PALRNKPAGG
GDEQPAPQRG ANVTSPPDRA PGLRGPPGPG GRDLPPRDLP PRDGPRDIPR RDGPRRDGPN
RNSGANNAGN ADSANWRR
