EIF3A_CANAL
ID EIF3A_CANAL Reviewed; 930 AA.
AC Q59PL9; A0A1D8PFI6; Q59PE8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=RPG1A {ECO:0000255|HAMAP-Rule:MF_03000}; Synonyms=TIF32;
GN OrderedLocusNames=CAALFM_C112770WA; ORFNames=CaO19.13701, CaO19.6345;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; CP017623; AOW26892.1; -; Genomic_DNA.
DR RefSeq; XP_711563.1; XM_706471.2.
DR AlphaFoldDB; Q59PL9; -.
DR SMR; Q59PL9; -.
DR BioGRID; 1229849; 3.
DR STRING; 237561.Q59PL9; -.
DR PRIDE; Q59PL9; -.
DR GeneID; 3646816; -.
DR KEGG; cal:CAALFM_C112770WA; -.
DR CGD; CAL0000181001; RPG1A.
DR VEuPathDB; FungiDB:C1_12770W_A; -.
DR eggNOG; KOG2072; Eukaryota.
DR HOGENOM; CLU_002096_2_1_1; -.
DR InParanoid; Q59PL9; -.
DR OrthoDB; 967904at2759; -.
DR PRO; PR:Q59PL9; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IBA:GO_Central.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0043614; C:multi-eIF complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; RNA-binding.
FT CHAIN 1..930
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366356"
FT DOMAIN 355..533
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 130..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 72..125
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COILED 620..902
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
SQ SEQUENCE 930 AA; 106063 MW; FA2BF6A397214542 CRC64;
MAPPHKNHNF RPENVLKRAE DLIAVGQKEA ALDTLYELII SKRIRYLQVQ DLEPIASLLI
ELAVELRKGK LAKDALHQYK KNIQLSENGL ESVQTIVRKF IDLAEKKLDA AQTKADIKID
EEENAAAAAA ATSSAGAGGA GGDAGGAGAG GDDDLETAQT PESILLSAVS NTDSADRTER
ELVTPWLRFL WEAFRAVLDI LRNNSKLEIT YSAIVNQAFK FCLNFNRKAE FRRLCELLRT
HMQSVTTQTT TKTSGHNAID LSDAETVQRY LDQRFAQLNI AVKLELWQES FRSVDDVHSL
ITASKKAPKP NMMANYYENL ARIFAVSDNT LYHAAAWNKF FNLYSQSPLA TDEELKRYAS
VLVLSTLSIP QRVVQDVDEH KSKNSKLSSL LNLTHVPTRE GLIKSILSRS ILKYVDEPIQ
QLFELLEGGD FHPLSIKQEI SQLFQIIESD KEFKKYIPTL TEVILIRIFQ QVSQVYDAVK
LDFLISLGIF PDLEYSLSEL QVEDLIVNAV KDDLVSLTID HESGVVSFKS NPFDEIDQEF
ANAGTTTTNT ITTTTTIGTS RLQISPAELV RTQISKLAAT LSESIYLIDP NYEARQQQAK
QQALQRCIKD MVNEQQRIAD RSKILKDRKV AAEKRKREEE ERQARLRQEK LAMEQKLEQE
RLIAEQERKK LEKLEKEREL IKENEKRKIA EEINAKGIIK IDLNNLKELD TTKLQLMQIE
QLNKDKKELE TKLQATAKKA DHLERAYRRY ELNLLEADLE IQLDLEKKDY EFLKQSKINK
AKKDHDNAIE LKKRLQRILP DYSKFKSEID AKNEVKLKQL QKEAQIKFEK AKQERIESVK
KHRIEELKIR KERERKAAAE EAARQAKAAE MAKLKEELRI QKEKDEALAR KRAELEAAAA
AAAAPSSSPP PKKTMTFAER MRLKREGKLP
