EIF3A_CANGA
ID EIF3A_CANGA Reviewed; 951 AA.
AC Q6FK21;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=TIF32 {ECO:0000255|HAMAP-Rule:MF_03000};
GN OrderedLocusNames=CAGL0M01804g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; CR380959; CAG62399.1; -; Genomic_DNA.
DR RefSeq; XP_449423.1; XM_449423.1.
DR AlphaFoldDB; Q6FK21; -.
DR SMR; Q6FK21; -.
DR STRING; 5478.XP_449423.1; -.
DR EnsemblFungi; CAG62399; CAG62399; CAGL0M01804g.
DR GeneID; 2891193; -.
DR KEGG; cgr:CAGL0M01804g; -.
DR CGD; CAL0136403; CAGL0M01804g.
DR VEuPathDB; FungiDB:CAGL0M01804g; -.
DR eggNOG; KOG2072; Eukaryota.
DR HOGENOM; CLU_002096_2_1_1; -.
DR InParanoid; Q6FK21; -.
DR OMA; VMYQTTA; -.
DR Proteomes; UP000002428; Chromosome M.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0002188; P:translation reinitiation; IEA:EnsemblFungi.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; RNA-binding.
FT CHAIN 1..951
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366357"
FT DOMAIN 298..496
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 503..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..125
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COILED 496..532
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COILED 592..676
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COILED 704..779
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COILED 808..909
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COMPBIAS 504..540
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 110157 MW; DC6B47AEBB351A5A CRC64;
MAPPPLRPEN ALKRADELIS VNEKPAALQS LYEFITARRI RYATPSQVEP IVFKFLELGV
ELKKGKLIKD ALYQYKKLVH GSAEGLVSVG AVLRKFIDYV ETKLASEQAK AEEKQKEEVS
DDLEGGVTPE NLLSSVYEAD HSVAGFNDEA LNSWMRFSWE SYRTALDLLR NNSQLEITYS
GVVSRTMQFC LKHQRKNEFK RLAEMLRQHL DTANYHQSKF GSNQVDLSDA DTLQRYLDQR
FQLVDASVKL GLWHEAYKAA EDVYHLMKMT TRKPKSSTLA NYFENLVQIF LVSGDQILHT
LAWKKYFELY STNPNATEEE FKKIASTIFL SALSIQLDDL PNVRYNYQSR SYRLLDVETK
PTRKEVIQSI VEDDTIFSRV DAETKTLYEI MEVEFDGESF KGKFEAILPK LEGESYFANY
SVSLRDVIIR RMFVFASQKY EDISLNDLYS SVTFSSSFKL SEWDIEKQLL QAAVDDYVSF
QLDHEQNKVT FVKDPLVNFA AIKEEEVEEE EEEEEEEEEE EKEAEGAEGA EGDTEEGQEA
VAEPEPVIKR NYYIRKRLSE LYEKLLEDTD YNTVSYLDKV RIAREALIKH TKDTIEDMKK
NSEERAKMHQ ERRRQHMESA AMNAEKDAEQ RQKRIMEERA SIEAKLEEEA HRRLIEKKKR
EFEEVKQREI RKLVDELNAK GNGTKVEYDE VKDMDIPDIT KYFVNRLSKN KDELEERMNF
AVKRMDHLER AYRKVELPLL KKQADELRAT DEVNFGNMKK KIVDAAKAEY EAKMEDYNRV
SSVFDDYKTL RDRMLAAHNE KFAAIRAENA AKLEAAKKAR IEEVRKQRYE ELLARSEAEK
KAAEEAERRA KLDEIARKQR EMEEALERKS AARTFTQPRA PVVPNANLDE IARKQREMEE
AIERKLAGKS AAPAPAPAPA ASTPAASTPA APGKMSFAER MRLKRQQQQQ K
