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EIF3A_CRYNJ
ID   EIF3A_CRYNJ             Reviewed;         952 AA.
AC   P0CN42; Q55S53; Q5KGK5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
GN   Name=TIF32 {ECO:0000255|HAMAP-Rule:MF_03000}; OrderedLocusNames=CNE03290;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC       Rule:MF_03000}.
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DR   EMBL; AE017345; AAW43583.1; -; Genomic_DNA.
DR   RefSeq; XP_570890.1; XM_570890.1.
DR   AlphaFoldDB; P0CN42; -.
DR   SMR; P0CN42; -.
DR   STRING; 5207.AAW43583; -.
DR   PaxDb; P0CN42; -.
DR   EnsemblFungi; AAW43583; AAW43583; CNE03290.
DR   VEuPathDB; FungiDB:CNE03290; -.
DR   eggNOG; KOG2072; Eukaryota.
DR   HOGENOM; CLU_002096_2_1_1; -.
DR   InParanoid; P0CN42; -.
DR   OMA; VMYQTTA; -.
DR   OrthoDB; 283412at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IBA:GO_Central.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR   GO; GO:0043614; C:multi-eIF complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR   GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR   HAMAP; MF_03000; eIF3a; 1.
DR   InterPro; IPR027512; EIF3A.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR14005; PTHR14005; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..952
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   A"
FT                   /id="PRO_0000366360"
FT   DOMAIN          315..491
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          757..952
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          522..849
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT   COMPBIAS        757..800
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        808..843
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        900..914
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   952 AA;  106269 MW;  996635B7FD0069C6 CRC64;
     MPPIYVKPEN ALKRSEELLA LGTPQSQQQA FDNLVEVFQS KRFKQTPINV LEPIVTKFID
     LCVVLSRKAH AKSGLLVFKS AAQTTNVGAI ERVLNHFIAK AEARLAAAVE QAKKEVAALP
     DVPVVDDDLP LQPASLMLDC FVDSAGDRER IERRLIAPAQ KFCWDSYDIC LDIAKSNDRL
     EVIYQSIAHR AFHFCKIHQR KADFRRLCEQ RLRKDLANAA KYSHQQHAIN LSDPETLGRF
     LDTRFLQLET AVELELWQEA FRSIEDVHGL IAGRKGTKPS MMANYYEKLT QIFKAEGGKQ
     TAVFHAAAWA RYFQHAERAG IVNDKASGCV LLSALAVPLG EVEVKQRLVA LLNLPKTPTR
     EALVQDAAAK HLKRVPADIR QIYKILEVDF EPTTASKVLA PLITSLSPEY QPYLPALRDV
     VLSRLLQALA QVYDSVTLSH ILDLVKPLDN TPWATDMSSL EKFLVTACRR GDIRASVDHV
     AQTITFVSTP PDANGLQTLA VCLYNTIQYL NPSRLAPVSR SDAFAAAIAQ AEEERKAASH
     KRQIVIRRRE LLEEAKLRRE KEASTALAER LKIKAEEDAR RAKEEAKQAE IDRVRKQIHE
     TKQAEAKQLA ASLAAQGALK VDISSIEDLD SSKLVAMQVE QLAKEKKELS ERLRIVGKRV
     DHLERAMRKE ERPLLAQDYE RQKAEDRAAH DRANQIAREQ AIEQQRAARE LKQRLGRMLE
     DYEAVKERIE SQMQEELKAA KEEARRKIEE EKAQLREKVI KRKREEKERK LKEAREAEER
     KRKEEEEAAQ KAEEEARAAA ALEAEAAAAE QRRAEREAQR QSDLERIRAQ QEREEEALRR
     RQAEKAAATS GGSAYRPPAR AGTTPPTASP APSSGGPSWL ARRKAMEAQS AGGAPVASSP
     KPVPSNSAAA SAPASNGPES IAGEAEKPAL TGSVWRRGMG ARRGMPSTRG GA
 
 
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