位置:首页 > 蛋白库 > EIF3A_CULQU
EIF3A_CULQU
ID   EIF3A_CULQU             Reviewed;        1149 AA.
AC   B0W6N3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000255|HAMAP-Rule:MF_03000};
GN   Name=eIF3-S10 {ECO:0000255|HAMAP-Rule:MF_03000}; ORFNames=CPIJ002784;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC       Rule:MF_03000}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDS36707.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS231848; EDS36707.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001844367.1; XM_001844315.1.
DR   AlphaFoldDB; B0W6N3; -.
DR   SMR; B0W6N3; -.
DR   STRING; 7176.CPIJ002784-PA; -.
DR   EnsemblMetazoa; XM_038250124.1; XP_038106052.1; LOC6033979.
DR   GeneID; 6033979; -.
DR   KEGG; cqu:CpipJ_CPIJ002784; -.
DR   VEuPathDB; VectorBase:CPIJ002784; -.
DR   VEuPathDB; VectorBase:CQUJHB011721; -.
DR   eggNOG; KOG2072; Eukaryota.
DR   HOGENOM; CLU_002096_1_1_1; -.
DR   InParanoid; B0W6N3; -.
DR   OrthoDB; 967904at2759; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03000; eIF3a; 1.
DR   InterPro; IPR027512; EIF3A.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR14005; PTHR14005; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..1149
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   A"
FT                   /id="PRO_0000366333"
FT   DOMAIN          317..498
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          496..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..1149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        811..885
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        954..975
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        982..1094
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1112..1149
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1149 AA;  133631 MW;  B0BED34CCFE0F40B CRC64;
     MSRYMQRPEN ALKRANEFIE VGKPARALDT LQEVFRIKKW TYTWSEAVIE PIMFKYLDLC
     VELKKSHIAK EGLFQYRNMF QMLNVGSLEN VIRGYLKMAE ERTEAAQQQS SQAILDIDDL
     DNLATPESIL MSAVCGEDAQ DRSDRTILLP WVKFLWESYG QCLELLKVNS HCENLYHDIA
     KMAFAFCLKY NRKMEFRKLC EKLRKHLDDI SKVSSQTANV SISKPETQQL NLDTRLNQLD
     CAIQMELWLE AYKAIEDIHG LMTLSKKTPM PKTMALYYQK LAMVFWKAGN QLFHAAALLK
     LFQLSRDMKK NVTQEEIQRM TSHVLIATLA IPLPSAHPEF DRFIETDKSP LEKAQKLAVL
     LGLQQPPSRV SLLKEVLRLN VLQLAAPQFQ NLYKWLEVEF DPLNLCSRVQ GVIEEITADE
     NSPYTQYTQA LQDVTLVRLV RQVSQVYQSI EFSRFLSLAK FANSFYLERI LVDCVRHNDM
     QITIDHRNHS VHFGTDLSES QREDHPDGPT LQSMPSEQVR SQLVNMSVVL HRAIATINPN
     RKKADRERLR NQMVKNYEEN MVKDHQRILQ RQKKIEDRKE YIERVNLERE ELEQRQLEEA
     ARQQKLAEMR RLEQENEERE RKRHENEIQM IKERNMKDKI DQIKQSASGQ KLLKKIDEED
     IKKMNAEEIA AKEAEERQKE RKAHDNNLKS QEKKIDYFER AKRLEEIPLI EKYLEDKLVQ
     DKEFWEKQEA SRIEAAIAER KNAEQVQERL RRMQADRDVF WQKLKGERSN AFAEKLKVFN
     AALEEERRRR LAERVIQRRE ERRQKWLREK EEERRRIEEE LRKQREEEER IERERRAEER
     RIENEKQRVI MEKQRAKEEE IERKLAEEKE RLKERAPRGE KEERGGGGGG GGAWRGRGDT
     AAPAESAAKP ESDWRNAREA REPAPESAGA SSAAAPAPKK DGVWQPSGRF REGRGAPGAD
     RPPRGDDREP PAAAAGESKW RRGGGGADDD KDDGPRPRVG AGDRGPMRRG DGDRDDRGPM
     RRGDRPPMRD GDRPGMRRDD RGDRREGGAP DRRDFGGRGG DRRDDRRDDR GPRREGGGER
     GGDVWRRAPQ EDRRGGAAGG ESGGNWRNAR QAEPAKPREE RRGGEERPKE ARAAAGPDED
     GWTDVKHHR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024