EIF3A_DROER
ID EIF3A_DROER Reviewed; 1135 AA.
AC B3P211;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
GN Synonyms=eIF3-S10 {ECO:0000255|HAMAP-Rule:MF_03000}; ORFNames=GG11565;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; CH954181; EDV47784.1; -; Genomic_DNA.
DR RefSeq; XP_001978826.1; XM_001978790.2.
DR AlphaFoldDB; B3P211; -.
DR SMR; B3P211; -.
DR STRING; 7220.FBpp0130111; -.
DR EnsemblMetazoa; FBtr0131619; FBpp0130111; FBgn0103862.
DR GeneID; 6552153; -.
DR KEGG; der:6552153; -.
DR eggNOG; KOG2072; Eukaryota.
DR HOGENOM; CLU_002096_1_0_1; -.
DR OMA; VMYQTTA; -.
DR OrthoDB; 152929at2759; -.
DR PhylomeDB; B3P211; -.
DR ChiTaRS; eIF3-S10; fly.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis;
KW RNA-binding.
FT CHAIN 1..1135
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366335"
FT DOMAIN 319..501
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 588..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..974
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1083
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 908
FT /note="Phosphoserine"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
SQ SEQUENCE 1135 AA; 133539 MW; 0C6DC4BD90406E94 CRC64;
MARYTQRPEN ALKRANEFIE VGKPLRALDT LQEVFRNKRW NYAYSETVIE PLMFKYLYLC
VELKKSHIAK EGLFQYRNMF QLVNVNSLEN VIRGYLKMAE EHTEAAQAQS SAAVAVLELD
DLDNIATPES ILMSAVCGED AQDRSDRTIL LPWVKFLWES YCQCLELLRV NTHCEALYHD
IARMAFQFCL KYNRKSEFRR LCDKLRKHLE DICKSSNQTT GVSINKVETQ QLCLDTRLYL
LDSAIQMELW QEAYKAIEDI HGLMALSKKT PVPKTMANYY QKLAMVFSKA GNQLFHAAAL
LKLFQLTREL KKNLTKDDLQ RMAAHVLLAT LSIPLPSAHP EFDRFIEADK SPLEKAQKLA
VLLGLPQPPT RVSLIREVVR LNVPQLVSED FRNLYNWLEV DFNPLNLCKR IQSIVDFIEN
GSENALLTPY IQSLKDVTIM RLIRQISQVY ESIQFQRLLQ LASFCNIFEL EKLLVESVRH
NDMQIRIDHQ KNSIYFGTDL TESQREYRPD GPALQSMPSE QIRSQLVNMS TVLTRAVSIV
YPNRERDQRA KLRTQMVNHY HEIKDREHQR ILQRQKIIED RKEYIEKQNN AREEEEARRQ
EEESRKAKLA EQKRLEQEQE ERERKRHQNE IQAIREKSLK EKVQQISQTA HGKKMLSKLD
EEGIKKLDAE QIAKRESEEL QREAKELQSK LKSQEKKIDY FERAKRLEEI PLFEKYLAEK
QVKDKEFWEA TEKTRIENAI AERKDAVGQQ ERLKRMYPDR DEFLEALKKE RASLYVEKLR
KFEAALEAER KKRLADRIIR RREERRQAFL REKEEERLRK EEEIRLAQAA EERAAAEARR
LEREADDEKR RAQYEKQRAK EEEAERKIKE DRERLARDLA SERERTEKER DTWRPRGGDR
PSAPAVGSGE WRRAAPTASE RNERGGERIE RGGDRIERGG ERIERGGDRD RDRKDNEGAD
SSWRVRREPD SQRAAAPKDS NAQQSRDDKW RRGGERDRDF RNDGPRRDRD DGPRRERDDG
PRRDRDDERG FRRNDGPRRT EEPQRETGGN WRDAPRNADR ENRRPAGERR DRDVRETRGD
QRGSAPKEAS SGGGGGNWRT APAAREEKPA SKRDQPQEKE NKAADDGEWT SVKRR
