EIF3A_DROMO
ID EIF3A_DROMO Reviewed; 1129 AA.
AC B4KA44;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
GN Synonyms=eIF3-S10 {ECO:0000255|HAMAP-Rule:MF_03000}; ORFNames=GI22072;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; CH933806; EDW16719.1; -; Genomic_DNA.
DR RefSeq; XP_002001258.2; XM_002001222.2.
DR AlphaFoldDB; B4KA44; -.
DR SMR; B4KA44; -.
DR STRING; 7230.FBpp0171289; -.
DR PRIDE; B4KA44; -.
DR EnsemblMetazoa; FBtr0426343; FBpp0384039; FBgn0144801.
DR GeneID; 6575244; -.
DR KEGG; dmo:Dmoj_GI22072; -.
DR eggNOG; KOG2072; Eukaryota.
DR HOGENOM; CLU_002096_1_0_1; -.
DR InParanoid; B4KA44; -.
DR OMA; VMYQTTA; -.
DR OrthoDB; 152929at2759; -.
DR PhylomeDB; B4KA44; -.
DR ChiTaRS; eIF3-S10; fly.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW RNA-binding.
FT CHAIN 1..1129
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366338"
FT DOMAIN 319..502
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 590..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1129 AA; 133033 MW; 895692827C819EC3 CRC64;
MARYTQRPEN ALKRANEFIE VGKPLRALDT LQEVFRNKRW NYAYSETVIE PLMFKYLYLC
VELKKSHIAK EGLFQYRNMF QLVNVNSLEN VIRGYLKMAE EHTEAAQAQS SAAVAVLELD
DLDNIATPES ILMSAVCGED AQDRSDRTIL LPWVKFLWES YCQCLELLRV NTHCEALYHD
IARMAFQFCL KYNRKSEFRR LCDKLRKHLE DICKSSNQTT GVSINKVETQ QLCLDTRLYL
LDSAIQMELW QEAYKAIEDI HGLMAMSKKT PVPKTMANYY QKLAMVFSKA GNQLFHAAAL
LKLFQLTREL KKNLTKDDLQ RMAAHVLLAT LSIPLPSAHP EFDRFIEADK SPLEKAQKLA
VLLGLPQPPT RVSLIREVVR LNVPNLVSED FRNLYNWLEV DFNPLNLCKR IQSIVDTIEA
SETENTLLTP YIQSLKDVTI MRLIRQISQV YESIEFKRLL ELAPFCNIFE LEKLLVESVR
HNDMQIRIDH QRNSIYFGTD LTESQREYRP DGPTLQSMPS EQIRSQLVNM STVLTRAVSI
VYPNRERDQR AKLRSQMVQH YHEIKDREHQ RILQRQKIIE DRKEFIEKQN NAREEEEARR
HEEESRKAKL AEQKRLEQEQ EERERKRHEN EIQAIKEKSL KEKVQQISQT AHGKKMLSKL
DEEGIKKLDA EQIAMRESEE LQRERKELQS KLKSQEKKID YFERAKRLEE IPLFEKYLAE
KNVKDKEFWE ATEATRIENA IAERKDAVSQ QERLKRMYPD RDEFLEALKK ERASLFVEKL
KKFEIALAEE RKKRLAERVV RRREERRQAY LRAKEEERFR KEEEIRLARE AEERAAAEAR
RLEREAEDEK RRQQYEKQRA KEEEAERKIQ EDRERLAREV AVERERSEKE RDVWRPRGDR
SERPSAAPAG GASEWRRNAP TSDRNDRNDR NERNDRSDRN DRNDRSERIE RSDRNDRPER
KDTDGGADSS WRVRREPVEP QRERGGGAGG GPSGRDDKWR RGGDRSERLG GDRDRDRDRD
SFRRNDGPRR DDDRGGFRRD DQPQRDTGSN WRDSPRQNDR DNRDNRRPAG DRRDIRGAGP
KEGGGGGGGG NWRTAPSPRD EKPPVKRDQP QDKENKAGDD GEWTSVKRR
