EIF3A_KLULA
ID EIF3A_KLULA Reviewed; 925 AA.
AC Q6CT90;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=TIF32 {ECO:0000255|HAMAP-Rule:MF_03000};
GN OrderedLocusNames=KLLA0C14498g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; CR382123; CAH01700.1; -; Genomic_DNA.
DR RefSeq; XP_452849.1; XM_452849.1.
DR AlphaFoldDB; Q6CT90; -.
DR SMR; Q6CT90; -.
DR STRING; 28985.XP_452849.1; -.
DR PRIDE; Q6CT90; -.
DR EnsemblFungi; CAH01700; CAH01700; KLLA0_C14498g.
DR GeneID; 2892152; -.
DR KEGG; kla:KLLA0_C14498g; -.
DR eggNOG; KOG2072; Eukaryota.
DR HOGENOM; CLU_002096_2_1_1; -.
DR InParanoid; Q6CT90; -.
DR OMA; VMYQTTA; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0000131; C:incipient cellular bud site; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0002188; P:translation reinitiation; IEA:EnsemblFungi.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; RNA-binding.
FT CHAIN 1..925
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366363"
FT DOMAIN 324..498
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 108..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 534..666
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COILED 785..885
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COMPBIAS 514..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..880
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 107109 MW; 5B99CBD1FEE769D0 CRC64;
MAPPALRPEN AIRRADELVS VGEPMAALQS LFDLLSSRRS RFADAATLEP IIFKFLELGV
ELRKGKMIKE GLYQYKKHMQ HTPEGLISVG AVARKFIDLI ETKMTNIQAQ TDAKEESNKD
QAEEDLEGGV TPENLLVSVY EQEQTVGGFN NDDVSAWLRF TWESYRTTLD FLRNNSQLEI
TYAGVVNRTM QFCYKYNRKN EFKRLAEMLR QHLDAANYQQ QRYGHHTVDL SDPDTLQRYS
DQRFQQVNVS VKLELWHEAF RSIEDVHHLM RLSKRAPKPS VLANYYENLA KIFFVSGNYL
LHAAAWEKFY NLYLKNPNAS EEDFKFYSSQ FVLSALAIQL DDLPIAGFDP QIRLCDLLDL
ESKPKRKDLI TAAGEQQVVE KADADILKFF NILETNFDVK SAKSQLSALL PNLVEKPYFA
QYVAPLRNLF IRRSIIEVSK AQTSIHLVEL HEMLSLPAPF ELSVFELEKY LIQAAMDDYV
SISIDHETDT VSFAQDPFDA WQASLVEVPE SSTSDEAKNS ESEEETSQET HADEEQNEQV
FTRNSEVRSK LTDLSKILKA NEEYENGSYY YRVKLVREEL IRRKEEVIKL EKEAAEIRAK
SNAERKKRSE EENKILAKKA LEERQRRMAE EKAAVESSME KEAERRAEEM MEREREAIHE
QEMKKLIAET NANGVIHIDP KEAKNLTSDK INQMVIEQVA KNKKDLTERM TYAFKKLDHL
ERAYRQMELP LLEKDAEEQK KRDRENYDNF KKKLIETSKA DYEKKLALHQ RLNKIYSTFN
QYKSSVIAEK KEELEKQRAL KEAQLEEAKK QRIEQVRKER YEAKVAEIQA AIEAEAAEKE
ALAKEEELAK RRAERERINK ERDEIARKQR EIEELLEKKN GSSRSSPVPS TPTPAPAPAQ
TAPVSNKPMS MAEKLRLKRM NAGRG
