位置:首页 > 蛋白库 > EIF3A_NEMVE
EIF3A_NEMVE
ID   EIF3A_NEMVE             Reviewed;         953 AA.
AC   A7SK48;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000255|HAMAP-Rule:MF_03000};
GN   ORFNames=v1g190699;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC       Rule:MF_03000}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDO35952.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS469683; EDO35952.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001628015.1; XM_001627965.1.
DR   AlphaFoldDB; A7SK48; -.
DR   SMR; A7SK48; -.
DR   STRING; 45351.EDO35952; -.
DR   GeneID; 5507362; -.
DR   KEGG; nve:5507362; -.
DR   eggNOG; KOG2072; Eukaryota.
DR   HOGENOM; CLU_002096_2_2_1; -.
DR   InParanoid; A7SK48; -.
DR   OrthoDB; 967904at2759; -.
DR   PhylomeDB; A7SK48; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IBA:GO_Central.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR   GO; GO:0043614; C:multi-eIF complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR   GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR   HAMAP; MF_03000; eIF3a; 1.
DR   InterPro; IPR027512; EIF3A.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR14005; PTHR14005; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..953
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   A"
FT                   /id="PRO_0000366346"
FT   DOMAIN          323..504
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          603..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          810..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          893..953
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          593..642
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT   COILED          670..704
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT   COILED          732..877
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT   COMPBIAS        896..946
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   953 AA;  113352 MW;  22EEBDD6092BFFAF CRC64;
     MPTYFQRPEN ALKRANEFIE VGKKEPALDA LYDVIKSKKH RTWQNKIHEP ILFKYLELCV
     DLRRSHVAKE GLYQYKLICQ QVNIASLEDV IRYFLKLAES RAVEAQEDSR KEASAELDED
     VDIEDLDQIQ TPESLLLSFV SGEDTQDRTD RVKLTPWVKF LWEAYRNVLE LLRNNVRVEK
     LYHETAQQAF KFCLKYTRRT EFRKLCDNLR NHLNVTLKHQ GQPNSVNLNN PDSIQMHLET
     RLAQLDSAIS MELWQEAFKA VEDVYGLMQL SKRPPKPQVM ANYYQKVALV FLKAGNFLYH
     ACTQQRLYLL MREQKKSITS EELQKMASHV LLATLSVPIQ VSLSNTEKYL ELDEVAREKS
     KRLANLLNLQ NTPTRESLLQ DMLKANVLQY VNTKVHCLYQ LLEKDFRPLD LCAKVNEVCQ
     YLESCDDADL CQYIKPIQNI AVTRLLKQVS QVFQTIEFSR LMALVPFMTE FQLERMIVDI
     AKEKNLQVRL DHRTKSISFG LDLHVAHREE VPEGPYLQAM PSEGLRNQLT LMSVALQRSI
     FTIQHDHIKA KKREEQEQMA QNYLRTARKE HKLMLERKTV IEARKEYLES VMQERERREY
     EKIKKQKVEN QEAEQKRLDE ERRQREIQRR RQELQDIEKR QAMDKIAALK KTTVGAKALK
     DLSPEEIDNM NADDIIAKQV EQLDKEKREL QTKLKTQEKK VDYFARAMRM EEIPLLNKQY
     EEHLVADREF WENQEEERVR KAIEEHEKLV ETSARLQRMI PDKDAFINTL RESRTEEYQA
     KFQAFQAKLE QVRKERLEVR RKRRIKDRKE RKKIEMEEAK KREQEEKERK KEEKERIERE
     EREAKEREYA ERIAKQNEID RKRREKELEI ERRLEERAGV GQVQQIRCLF ITGWGDHEDG
     GDRWRDERGG DRGPDRGGDK PGAWRPKWQR EEPDRGGDRW RGGDRRDGMI TMS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024