ID   EIF3A_NEUCR             Reviewed;        1059 AA.
AC   Q7RWT1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
DE            Short=eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03000};
DE   AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
GN   Name=eif3a; Synonyms=tif32; ORFNames=NCU00040, NCU20009;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC       Rule:MF_03000}.
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DR   EMBL; CM002238; EAA26915.3; -; Genomic_DNA.
DR   RefSeq; XP_956151.3; XM_951058.3.
DR   AlphaFoldDB; Q7RWT1; -.
DR   SMR; Q7RWT1; -.
DR   STRING; 5141.EFNCRP00000000281; -.
DR   EnsemblFungi; EAA26915; EAA26915; NCU00040.
DR   GeneID; 3872303; -.
DR   KEGG; ncr:NCU00040; -.
DR   VEuPathDB; FungiDB:NCU00040; -.
DR   HOGENOM; CLU_002096_2_1_1; -.
DR   InParanoid; Q7RWT1; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IBA:GO_Central.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR   GO; GO:0043614; C:multi-eIF complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR   GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR   HAMAP; MF_03000; eIF3a; 1.
DR   InterPro; IPR027512; EIF3A.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR14005; PTHR14005; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..1059
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   A"
FT                   /id="PRO_0000366367"
FT   DOMAIN          337..521
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          794..1059
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          99..130
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT   COILED          586..905
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT   COMPBIAS        794..903
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1059 AA;  120243 MW;  6F0FCFE206B2299D CRC64;
     MPPPPHQKPE NVLKRAHELI GVNQAPAALT LLHEHITSKR SRNVPIASLE PVMLLLVELS
     VEQKKGKLAK DALYQYKNIA QNTNVATIEL VLKKFIELAA EKVTAAQAKA DEVQSSIEAT
     TSNIDDLEAS ETPESILLAT VSGEQSRDRT DRAIVTPWLK FLWEAYRTVL DILRNNARLE
     VLYQSTAMQA FDFCLKYTRK TEFRRLCELL RNHVQTAAKY SAQMHAINLN DPDTLQRHLE
     TRFQQLNVAV ELELWQEAFR SVEDIHTLLS LSKRPAKNVM MANYYEKLTR IFLVGENYLF
     HAAAWARYYN LLRQSAALIA SGHSKKADNP ACSDADLQRA ATFVILSALS IPVISTSRSR
     GAMVDFDEAR KNKNSRLTHL LGMAQAPTRA GLFRDALSKS LLRRAQPQIR DLYNILEVDF
     HPLSICQKIS PILAEIGADA EMQKYILPLQ QVILTRLFQQ LSQVYETVDL EFVESLAQFP
     EPFQVTRGTI EKFIMNGNKK GDLAIRMDHA TGVLSFDADV FSSAKAVHAG SSAGSAESET
     GSVQRLQSTP SQIVRSQLTR LAEALYTTCR YIDPSFNEAR IKARDEALAR AKAGAEKEHQ
     EVLARKEIIQ TRKDKASEAQ AQKEKENARK KLLQEQALQQ AEAARLAEEQ KLREAKRLAN
     EREQIKRKEV EALLKDMKLE ELQGEDIETL DSNKIRMIKL QQLEREKNSV AEKLRITGKR
     LDHLERAFRK EEAKKLPEDY AKQRERDLAA YERTKAQTLK EAELKHKADV ELKHRLTRLM
     PFYESFRSDL HERRRDEFEK RRRDAEREME KQINARRKEA REKRIREKRE REERERQLRE
     AEERAAREKE EERKRLEARR EELQRLKEEK EKEREKLREI AARQQQREEE AMARRKAEKE
     KLAATPSAYR PPAAAERTEA AAPPRIALAG NRPSWREREA AKAASGETAA PAPAAAEPVA
     ERPRAAAPPA ERTEAAAPPR LALAGNRPSW REREAAKAAS GGGNAAAVPE RSAPPLRAAA
     PQRAGSGRPE NDRDVPPAEP LKASGAPGKY VPKWRREGA