EIF3A_USTMA
ID EIF3A_USTMA Reviewed; 1024 AA.
AC Q4P358; A0A0D1CHM7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=TIF32 {ECO:0000255|HAMAP-Rule:MF_03000}; ORFNames=UMAG_11577;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; CM003157; KIS66463.1; -; Genomic_DNA.
DR RefSeq; XP_011391954.1; XM_011393652.1.
DR AlphaFoldDB; Q4P358; -.
DR SMR; Q4P358; -.
DR STRING; 237631.Q4P358; -.
DR PRIDE; Q4P358; -.
DR EnsemblFungi; KIS66463; KIS66463; UMAG_11577.
DR GeneID; 23567442; -.
DR KEGG; uma:UMAG_11577; -.
DR VEuPathDB; FungiDB:UMAG_11577; -.
DR eggNOG; KOG2072; Eukaryota.
DR InParanoid; Q4P358; -.
DR OrthoDB; 967904at2759; -.
DR Proteomes; UP000000561; Chromosome 18.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IBA:GO_Central.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0043614; C:multi-eIF complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0002188; P:translation reinitiation; IBA:GO_Central.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; RNA-binding.
FT CHAIN 1..1024
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366369"
FT DOMAIN 331..508
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 797..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 575..717
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COILED 777..889
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT COMPBIAS 797..887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 115537 MW; E4C703ABCAD6D58C CRC64;
MPPFAKPETV LKRSEELINV GQHQAALAAL NEIFTSRRFK QTPLQSLEPI MLRFVDLCVD
LKKGRMAKEG LMQYKNVSQN TNAQSIELVI KHFIKLADAK VVEAQSKADA AVGEIDVDDL
EESETPESML LGSVSADQNK DRTDRVLVTP WLKFLWEAYR TALDILRNNA RLEVPYQQIA
NQALKFCLQY QRKTEFRRLC EVLRQHLQNV ARYSHHAHAI NLTDQDTLQR HLDTRFAQLN
SAVELELWQE AFRSVEDIHN LLTMAKKAPR PAMMANYYEK LARIFMVSDN NLFHAAAWNR
YYALARSIAK SEQEHTQIAS YVLISALAVP VISSNAPGTG NLHKSKSDFL QADHEARSRT
GRLTSLLGLS RTPTRAGLLK EALNRDILKK ARPELRELYN ILEVEFHPLS ICAKIEPILA
SISQDAEMAK YVKPLHSVVL TRLFQQLSQV YDAVKLSKVM QLVSAFKAPH SYTPAEIEKF
CLNACKKGHL NIRIDHVAQA ITFQDDVFST DVHPAASASS EADNVGLQAS PSELVRTQLS
RLATCLDTTL KTIDPTILAD AQAAKRHVFA RAVAAAEDEH KAAIARKALL ARRKELLEEM
ATRKEREEAA ARAERARAAA EAEQKRIAEE QKKREQDRLN KEVEAVRIEE AKKMAKSLQE
RGGLKLSEEE LANLDTDKLV QMQVEQIEKE KKELAERLRL IHRRMDHLER AYRREEAPLL
SADYERQKQE DLQYHKAARI TLLQTSKDKH AADLEIKKRL TRILPDYQQL RSIIEDKRRG
EFEERRRKAT EQIELEKERR RQQVRDERRR ERQEAEEAER RRVQEEQEAR ARAEEEERLA
EQRRVEEAQR AELEAKKRAE IEERRAKFQA TADKQRQREE EAEANRRSRA AGTGAAPAQE
LAAADATWRR ASGSPAPTQA ESQRPPIFGA ARTGGAGGWR ERLAAKEAAG GNATAAPSAP
AAAPAPASSG AYRPGMFRAA AGAGAGGRTD RVAATPLPPA AAAAESDGFT EVKKNVYRPP
GRRA
