EIF3A_XENLA
ID EIF3A_XENLA Reviewed; 1424 AA.
AC A2VD00;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 10 {ECO:0000255|HAMAP-Rule:MF_03000};
DE AltName: Full=eIF-3-theta {ECO:0000255|HAMAP-Rule:MF_03000};
GN Name=eif3a; Synonyms=eif3s10;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC eif3m. {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000255|HAMAP-
CC Rule:MF_03000}.
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DR EMBL; BC129055; AAI29056.1; -; mRNA.
DR RefSeq; NP_001085285.1; NM_001091816.1.
DR AlphaFoldDB; A2VD00; -.
DR SMR; A2VD00; -.
DR BioGRID; 101797; 2.
DR IntAct; A2VD00; 1.
DR PRIDE; A2VD00; -.
DR GeneID; 443632; -.
DR KEGG; xla:443632; -.
DR CTD; 443632; -.
DR Xenbase; XB-GENE-17338715; eif3a.S.
DR OrthoDB; 967904at2759; -.
DR Proteomes; UP000186698; Chromosome 7S.
DR Bgee; 443632; Expressed in pancreas and 19 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; ISS:UniProtKB.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005; PTHR14005; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03000"
FT CHAIN 2..1424
FT /note="Eukaryotic translation initiation factor 3 subunit
FT A"
FT /id="PRO_0000366329"
FT DOMAIN 315..498
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REPEAT 994..1003
FT /note="1; approximate"
FT REPEAT 1004..1013
FT /note="2"
FT REPEAT 1014..1023
FT /note="3"
FT REPEAT 1024..1033
FT /note="4"
FT REPEAT 1034..1043
FT /note="5"
FT REPEAT 1044..1053
FT /note="6"
FT REPEAT 1054..1063
FT /note="7"
FT REPEAT 1064..1073
FT /note="8"
FT REPEAT 1074..1083
FT /note="9"
FT REPEAT 1084..1093
FT /note="10; approximate"
FT REPEAT 1094..1103
FT /note="11"
FT REPEAT 1104..1113
FT /note="12"
FT REPEAT 1114..1123
FT /note="13"
FT REPEAT 1124..1132
FT /note="14"
FT REPEAT 1134..1143
FT /note="15"
FT REPEAT 1144..1153
FT /note="16"
FT REPEAT 1154..1163
FT /note="17"
FT REPEAT 1164..1173
FT /note="18"
FT REPEAT 1174..1183
FT /note="19"
FT REPEAT 1184..1193
FT /note="20"
FT REPEAT 1194..1203
FT /note="21"
FT REPEAT 1204..1213
FT /note="22; approximate"
FT REPEAT 1215..1224
FT /note="23"
FT REPEAT 1225..1234
FT /note="24"
FT REPEAT 1235..1244
FT /note="25"
FT REPEAT 1245..1254
FT /note="26"
FT REGION 821..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..1424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1254
FT /note="26 X 10 AA approximate tandem repeats of [DE]-[DE]-
FT [DE]-R-[GTV]-[PS]-R-R-G-[AFGLM]"
FT COMPBIAS 868..1259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1424 AA; 168500 MW; F0F2758D267F962E CRC64;
MPVYFQRPEN ALKRANEFLE VGKKQPALDV LYDVIKSKKH RTWQKIHEPI MLKYLELCVD
LRKSHLAKEG LYQYKNICQQ VNIKSLEDVV RAYLKLAEER TESAKESSQQ MVLDIEDLDN
IQTPESVLLS AVSGEDTQDR TDRLLLTPWV KFLWESYRQC LDLLRNNSKV ERLYHDIAQQ
AFKFCLLYTR KAEFRKLCDN LRMHLSQIQR HHNQSTAINL NNPESQSMHL ETRLVQLDSA
ISMELWQEAF KAVEDIHGLF ALSKKPPKPQ LMANYYNKVS TVFWKSGNAL FHASTLHRLY
HLSREMRKNL SPEEMQRMST RVLLATLSIP ITPERTDIAR LLDMDGIIVE KQRRLATLLG
LQSPPNRVGL IKDMVRFNAL QHVVPEVKEL YNWLEVDFHP LKLCTRVTKV LDWIKEQAEK
EPELQQYVPQ LQSNTVLRLL QQVAQIYQTI EFSRLSSLLP FVDAFLLERA IVDAARHCNL
QVRIDHTSRT LSFGSDLNYS TREDAPVGPF LQNMPSEHIR NQLTAMSTVL SKAVATIKPA
HVLQEKEEQH QIAISAYQKN SRKEHQRILT RRQTIEERKE RLENLNIQRE KEEHEQREAE
LQKVRKAEEE RLRQEAKERE KERILQEHEQ IKKKTVRERL EQIKKTEFGA KAFKDIDIEN
LEELDPDFIM AKQVEQLEKE KRELQDRLKN QEKKIDYFER AKRLEEIPLL KKAYDEQRIS
DMELWEQQEE ERISTLLVER EKAVEHKNRM SRMLEDRDSF VSNLKASRQS VYDAKLKQFQ
ERLAEEKRVR LEERKRQRKE ERRISYYRDK EEEEQRLIEE QLKQEREDRE KIENEKREAE
QREYQERLKK LEEQERKKRL RELEIEEREK KRDEERRGPD DSFRKQDTPS RWGDREESGW
RRGADPDERK QAPPERDWRS GGQDSKPVKD EDREGDEDSV LRKDEEQVAR GDGDEERAAS
WRGTDDRGPK RSVEEDGGPR RGFNDEPGPR RGFEDDQGPR RGLDEDRGPR RGLDEDRGPR
RGLDEDRGPR RGLDEDRGPR RGLDEDRGPR RGLDEDRGPR RGLDEDRGPR RGFDEDRGPR
RGFDEDRGPR RDFDEDRGPR RGFDEDRGPR RGFDEDRGPR RGFDEDRGPR RGFDDDRGPR
RGFDDDRGPR RGFEDDRGPR RGFEDDRGPR RGFEDDRGPR RGFDEDRTPR RGFEDDRGPR
RGMDEERVSW RGGAEEDRGP RRGAEEDRGP RRGAEEDRGP RRGAEEDRGP RRGAEEDRGQ
TPWKPVVTSR PASGGWRERE KAREDSWGPS HDSKPPEERD WSKRGEDGEK DSERDRRPVR
EESAWRRGGD DNVTPRKVSP GDKSTEDRKE PSDVRRAAPK TDEPSQWRQG EQKDSQQEER
GTPRRVAAAD REKPSWRTEK KEEKDAPRRP KLEEDEDGWT TVRR
