EIF3B_ASPFC
ID EIF3B_ASPFC Reviewed; 740 AA.
AC B0XRG7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=prt1; ORFNames=AFUB_002410;
OS Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; DS499594; EDP55546.1; -; Genomic_DNA.
DR AlphaFoldDB; B0XRG7; -.
DR SMR; B0XRG7; -.
DR EnsemblFungi; EDP55546; EDP55546; AFUB_002410.
DR VEuPathDB; FungiDB:AFUB_002410; -.
DR HOGENOM; CLU_011152_4_0_1; -.
DR PhylomeDB; B0XRG7; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Repeat; RNA-binding;
KW WD repeat.
FT CHAIN 1..740
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363808"
FT DOMAIN 40..126
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 193..230
FT /note="WD 1"
FT REPEAT 232..289
FT /note="WD 2"
FT REPEAT 302..343
FT /note="WD 3"
FT REPEAT 455..496
FT /note="WD 4"
FT REPEAT 513..556
FT /note="WD 5"
FT REPEAT 571..609
FT /note="WD 6"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 84487 MW; 5234765AA2D1682C CRC64;
MAPSFDTLSE QDLHEEEEEE IDFSDLKAQY EVKLEEGLDT FVVIDGLPVV PEESRQKLIK
FLLRKLNTVG HTSEDAVFMP LNDKNMSEGY AFVEFETPEQ AVAAVKQLHG TPLDKKHTLL
VNKLMDIERY GREGRIDEEY KPPAIEPFKE KEHLRSWLAD PNARDQFALY RGDKVGVFWN
NKNHPPENVV DRAHWTQLFV QWSPKGTYLA SVHPQGVQLW GGPAFSKQKQ FPHPFVQLIE
FSPGESYLTT WSARPIQVEE GQSILTYEEE GKNIIVWDIA TGKPLRSFVS HDLTAGPAGD
AEPKKKVQWP AFKWSADEKY VARMLQHQSI SIYELPRMNL LGKTSVKIDG VMDFEWSPAT
VTREGVKQYE QLLCFWTPEI GSSPARVAMM SVPSKEIVRT RNLFNVSDVK LHWQSQGLYV
CVKVDRHSKS KKSMATNLEI FRVREKGVPV EVVDSLKDTV INFAWEPNGN RFVLITTGEA
VAGAAVAPKT AVSFFAPEKK GGAIGNFKLI RTIEKKNSNA IYWSPKGRFV VVATVHSQTS
FDMDFWDMDF EGEKPEAEKD FAANLQLMKT TEHYGVTDID WDPTGRYVVS SASVWTHQLE
NGWNLHTFAG QTLSENPTDK FKQFLWRPRP PTLLSKEEQK QVRKNLREYS KEFDEEDRYA
VDIANTAVVE KRKRVLNEWI AWIRREKELL AEEKDAYGLP EEADDPKLAK DAAATTQEQG
ETVVEEIVEE IIEESEEVIG
