EIF3B_CAEBR
ID EIF3B_CAEBR Reviewed; 716 AA.
AC A8WX15;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 3.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255|HAMAP-Rule:MF_03001};
GN Name=eif-3.B {ECO:0000255|HAMAP-Rule:MF_03001,
GN ECO:0000312|WormBase:CBG04247};
GN ORFNames=CBG04247 {ECO:0000312|WormBase:CBG04247};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; HE600920; CAP24992.3; -; Genomic_DNA.
DR AlphaFoldDB; A8WX15; -.
DR SMR; A8WX15; -.
DR STRING; 6238.CBG04247; -.
DR PRIDE; A8WX15; -.
DR EnsemblMetazoa; CBG04247.1; CBG04247.1; WBGene00026961.
DR WormBase; CBG04247; CBP37633; WBGene00026961; Cbr-eif-3.B.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_1_0_1; -.
DR InParanoid; A8WX15; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR Proteomes; UP000008549; Chromosome II.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.120.10.30; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding; WD repeat.
FT CHAIN 1..716
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363788"
FT DOMAIN 45..129
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 195..233
FT /note="WD 1"
FT REPEAT 235..283
FT /note="WD 2"
FT REPEAT 345..386
FT /note="WD 3"
FT REPEAT 411..450
FT /note="WD 4"
FT REPEAT 453..495
FT /note="WD 5"
FT REPEAT 501..543
FT /note="WD 6"
FT REPEAT 545..585
FT /note="WD 7"
SQ SEQUENCE 716 AA; 81753 MW; 9A0F1F179F85E914 CRC64;
MVEIDFNKEN EEDYSDPADF VDDVTDDVLV PDVLYKKPTI DEFEGNVFIA GIPVVGAERI
ARLQSVLKKV LEKLEPGVKI FIPPSPEGGS LGVLLTEWPD SRSAAFAVKS LDGYSFDKNH
TFSARFFTDM KKLEAPSDAW TTPVKSEYSD VGDLWWWLQN ERCRDQFAIS HDKLGIPTVG
VFTNMKGNDP ELAGDPEKAE RANWTETVFT WSPHGSYLST IHKRGIILWG GKDYARAHRF
AHDNVQYIDF SPCETFLDTY LGRLEKKVPE SLGFRTGELK KAYSTFELTG RTQLPTWPFF
KWSIDEKYFA CLKAPEKDKL EREKKIDGIS IFESETFELV DKRAVTIENI KHFDWSPTAP
ILAYYSECTD AVPAEFGLLQ VPSMQRLRSA RVHNVADAQM FWQKSGKRLA FYTMRYKKKE
FRETGEVKYV GGCQYHVDIF EIDKKDVSLM NLPLAEPFIH FDWDPEGDKF CVLVGNTAKA
TPQVYKIEAN SHAPKLVSKL DAGVHFNEVQ FAPKGGWLAV LAKVSAGGNV YFIDTSLAEA
KRTNVIEHPL FNKGYWDPTG RYFVTCSTLG GRAGADLGYR IFTFQGRELC RKNLDRLAQF
KWRPRPPVKL SEQKQNEIRK NLKKTAAKFV KQDDDEKCRA SQEVVEKRRK IMAAFDVIRN
RNRECLENTR HLRIALRDGV DTEAQLDEDE FVDEEITIAL STSKTAAPLS EEDERD
