EIF3B_CANGA
ID EIF3B_CANGA Reviewed; 719 AA.
AC Q6FM92;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001};
GN OrderedLocusNames=CAGL0K09966g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; CR380957; CAG61615.1; -; Genomic_DNA.
DR RefSeq; XP_448652.1; XM_448652.1.
DR AlphaFoldDB; Q6FM92; -.
DR SMR; Q6FM92; -.
DR STRING; 5478.XP_448652.1; -.
DR EnsemblFungi; CAG61615; CAG61615; CAGL0K09966g.
DR GeneID; 2890208; -.
DR KEGG; cgr:CAGL0K09966g; -.
DR CGD; CAL0134205; PRT1.
DR VEuPathDB; FungiDB:CAGL0K09966g; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_4_0_1; -.
DR InParanoid; Q6FM92; -.
DR OMA; NVADCKI; -.
DR Proteomes; UP000002428; Chromosome K.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding; WD repeat.
FT CHAIN 1..719
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363814"
FT DOMAIN 35..119
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 184..222
FT /note="WD 1"
FT REPEAT 233..281
FT /note="WD 2"
FT REPEAT 329..372
FT /note="WD 3"
FT REPEAT 440..483
FT /note="WD 4"
FT REPEAT 503..548
FT /note="WD 5"
FT REPEAT 564..609
FT /note="WD 6"
FT REGION 1..217
FT /note="Sufficient for interaction with PIC8"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REGION 1..93
FT /note="Sufficient for interaction with HCR1 and TIF32"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 719 AA; 82424 MW; B431D0A5E18D16E7 CRC64;
MAAAEIKLED IPVDDIDFTD LEKEYSVDDE FKFDNYVVVT GAPVIPESKV PVLKKALGGL
FSKAGKVVDM EFPLDDDKKS KGFLFVECGS DVDAKKIIKA FHGKRLDLKH RLFLYSMRDV
EKLSEQGAGE FVEPELPGFV PTSTLKSWLA DEDGRDQFVI QKDNLTGIFW NSMHESEDDV
VESRTNWSTN YVRFSPRGTY LFSYHPQGVT SWGGPQFDRL RRFYHPNVRT SSVSPDEHYL
VTFSPEPIEL DDSVPESPFT KRNEGHHICV WEIDTGLLCA SFPLTKNPNL QWPFVKFSYN
DKYCARFVGD RLAVYDCTNK FSLLEAPALK VSGIRDFSFA PTGVELQPFN KNDEPSVLLS
YWTPETNNSA CTASVVQVPR GRVLKTVNLV QVSNVTTYWP EGGEYLVFNV ERHTKSKKTL
FSNLQICKLT EKDIPVEKIE VKDRIMEVGW EPHGHRFITI STTEGPDDNI AIPKNVVRFY
APEKKEGVKN KIVVKRWVVI KEIEKKFYNT VSWSPAGRFV TVCALVKPNM RKSEFQFFDL
DYPGEKNLNE RKDVLATLKD VGESNYGAAT DLCWDPSGRF LTAWSSSLKH KMENGYKMFN
IAGVIIKEDI LPNMKNFAWR PRPESLLSNA EKKKVRKTLK EWSAEFDEQD AMANDSAVRD
LILKQRAMLK EWREYRAAKA QTTTIFDIAP WLDTTKDHED FVKIEEIKEE IVEEIKEKL
