ID   EIF3B_CHAGB             Reviewed;         750 AA.
AC   Q2GM53;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE            Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE   AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE            Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE   AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN   Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=CHGG_10951;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC       Rule:MF_03001}.
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DR   EMBL; CH408036; EAQ83133.1; -; Genomic_DNA.
DR   RefSeq; XP_001226218.1; XM_001226217.1.
DR   AlphaFoldDB; Q2GM53; -.
DR   SMR; Q2GM53; -.
DR   STRING; 38033.XP_001226218.1; -.
DR   EnsemblFungi; EAQ83133; EAQ83133; CHGG_10951.
DR   GeneID; 4397283; -.
DR   eggNOG; KOG2314; Eukaryota.
DR   HOGENOM; CLU_011152_4_0_1; -.
DR   InParanoid; Q2GM53; -.
DR   OMA; NVADCKI; -.
DR   OrthoDB; 1194797at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd12278; RRM_eIF3B; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03001; eIF3b; 1.
DR   InterPro; IPR011400; EIF3B.
DR   InterPro; IPR034363; eIF3B_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR14068; PTHR14068; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   PIRSF; PIRSF036424; eIF3b; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; RNA-binding; WD repeat.
FT   CHAIN           1..750
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   B"
FT                   /id="PRO_0000363815"
FT   DOMAIN          42..128
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT   REPEAT          195..234
FT                   /note="WD 1"
FT   REPEAT          236..292
FT                   /note="WD 2"
FT   REPEAT          309..348
FT                   /note="WD 3"
FT   REPEAT          519..562
FT                   /note="WD 4"
SQ   SEQUENCE   750 AA;  85884 MW;  31EC746F41B4F583 CRC64;
     MAPSFDHLRD EDLDEEDFDM DEVDISDLRE KYEVQLEQGY DTFVVVDGLP EVNADQKPKL
     VKFLLKKLNS VGRVSEDSVY MPMGDNGLSL RFAFVEYSSP AEAAAAVRQL DFTPLDKKHT
     LRVNKMTDVD RYGREGRIEE EYTAPKIEEF QEKEHLRSFM ADPSERGRDQ FVMFRGETVG
     VFWNNEKDQP ENIVDRQQWT ETFVQWSPQG TYLTSVHAQG VLLWGGASWA RLRRFPHPFV
     NLVAFSPNEK YMVTWSNRPI SIPDSGHPAL SLDDDGKNYV IWDLETSKPL RSFAQQDTPA
     TGDDAAKKSA KFPWPAFKWS ADDKYVARLN QGTSISVYEL PKMNLMDKTA IKIEGVMDFE
     WAPATPRRDG VKTYEQLFCF WTPEIGSNPA RVGLMSIPSK QIVRSLNLFS VSDVKLHWQS
     DSAYICVKVD RHSKSKKSQA TTLEIFRVKE KGVPVEVVDT IKDTVINFAW EPKGDRFVII
     TTPEPVGAVA VAPKTSVAFF CPEKAKGNAI GNFKHLRTLD KKNSNAIYWS PKGRFVVVAA
     IANTQSSDLD FFDVDFEGEK PEGEKDLTAN LQLMNTSEHY GMTDIEWDPS GRYVATWASS
     WKHVMENGYH LYDFRGELLR EEAIEKFKQW SWRPRPATLL TKEEQKQIRK NLREYSRVFE
     QEDADRISSA DVAVVEARRR LLLEWVTWRE SMEEELVEDR AALGLPEDPV AELLRQKTAA
     ITPAAGEEQE EQVVEEIMEE VLEESEEIVN