EIF3B_CRYNB
ID EIF3B_CRYNB Reviewed; 753 AA.
AC P0CN45; Q55UP4; Q5KHP8; Q8J0V9;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; OrderedLocusNames=CNBD0640;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; AAEY01000019; EAL21368.1; -; Genomic_DNA.
DR RefSeq; XP_776015.1; XM_770922.1.
DR AlphaFoldDB; P0CN45; -.
DR SMR; P0CN45; -.
DR EnsemblFungi; AAW43191; AAW43191; CND05740.
DR EnsemblFungi; EAL21368; EAL21368; CNBD0640.
DR GeneID; 4935453; -.
DR KEGG; cnb:CNBD0640; -.
DR VEuPathDB; FungiDB:CNBD0640; -.
DR HOGENOM; CLU_011152_4_0_1; -.
DR Proteomes; UP000001435; Chromosome 4.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 2.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis; Repeat;
KW RNA-binding; WD repeat.
FT CHAIN 1..753
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000410076"
FT DOMAIN 42..129
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 142..185
FT /note="WD 1"
FT REPEAT 203..241
FT /note="WD 2"
FT REPEAT 321..362
FT /note="WD 3"
FT REPEAT 537..580
FT /note="WD 4"
FT REPEAT 595..640
FT /note="WD 5"
FT COILED 723..753
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 753 AA; 86204 MW; 5561BFF4D9C86DDA CRC64;
MSAADLDYFS EDEQREIEAE LDTGFKDIEE KYAVTAQKGF ETMLVVDNIP IVDGSKKQRL
LERLRQTFAK VGAPIEEESI DMPWNAAAGT NKGFVFLTYP DVKEAENAVH TLDGVSFGKN
VLHVNRFGDI QRFASMPVGE GDLPSGWKEK EYIEKDYLRN WLGDIAGRDQ YVTFWETEVT
VWWNGRNGTA EALKGPDGKP VKNSKWGELY LQWSTMGTYL ASLHRVGVAL WSGPKLDGPI
GVNVLRFTHP NVRLIQFSPC ENYLVTWSED PLPNYENHPN AALRDTFGPE DEGNQYVIWD
IKTTRVLRTF PGDKSAIGVD DTQSRMSWPT FKWSADDSYI AKCNVGAGIS VYELPTMGLL
DRKSIKIEGV QDFEWCPMSQ KDLIARQEGK GKECVLAFWT PEAQNQPARV NIMAVPSRTI
LRSKNLFNVS ECKFYWQSQG DFLCVKVDRH ARKAKSKKAT SCNLEIFRMR EKDYPVEVLE
FKDYVPQFAW EPSGTRFAIV LQAETNLPSV SGASTKYSID FYQLDSKKGD FIAIKHLDSK
MANTLVWSPK GRHIALATIG SSSKYDIEFW DLDFTIDERR EAAELGANVT MLGTGEHYGI
TEIAWDPSGR YIATSASTWR QSPEPGFSIW DFKGQQLLHE SRDRFKQFLW RPRPPTLLSK
DQIKKVRKEL REYSRQFDEE DAAEENRGSA EKLAQRRREI GEWNAWRTRN NDRLAFEREN
RGKSKAKIDV KGQEARVEEW VEELIDETEE LSM
