EIF3B_CULQU
ID EIF3B_CULQU Reviewed; 688 AA.
AC B0W562;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255|HAMAP-Rule:MF_03001};
GN Name=eIF3-S9 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=CPIJ002177;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; DS231841; EDS34809.1; -; Genomic_DNA.
DR RefSeq; XP_001843846.1; XM_001843794.1.
DR AlphaFoldDB; B0W562; -.
DR SMR; B0W562; -.
DR STRING; 7176.CPIJ002177-PA; -.
DR PRIDE; B0W562; -.
DR EnsemblMetazoa; XM_001843794.2; XP_001843846.1; LOC6033391.
DR GeneID; 6033391; -.
DR KEGG; cqu:CpipJ_CPIJ002177; -.
DR VEuPathDB; VectorBase:CPIJ002177; -.
DR VEuPathDB; VectorBase:CQUJHB012397; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_1_0_1; -.
DR InParanoid; B0W562; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR PhylomeDB; B0W562; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 2.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; RNA-binding; WD repeat.
FT CHAIN 1..688
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363793"
FT DOMAIN 57..141
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 208..246
FT /note="WD 1"
FT REPEAT 247..287
FT /note="WD 2"
FT REPEAT 291..329
FT /note="WD 3"
FT REPEAT 332..367
FT /note="WD 4"
FT REPEAT 440..482
FT /note="WD 5"
FT REPEAT 527..572
FT /note="WD 6"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 612..643
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT COMPBIAS 13..28
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 80124 MW; 2742A940D09D9561 CRC64;
MAKKKGDQYD SDGAEDQDYD EEPVFEDPAG FVDDVGDDEL LGDFLKQKPC ESDGVENVIV
VDNIPVVGPA RFPKLQGVLE KIFKNAGTIV NIHYPKDDEE NTKGFAFIEF KNPEMAEEAV
KAFNNYRLDK SHTLLVNLFS DFQKYSDIPK DWSPPESQPY KVQNDLYTFL SEPDAQDQFC
VVAESTPGAV QVQFWHNTQP EPVELLTRER FTETYVKWSP LGTYIVTFHK QGVVIWGGSS
FTKINKFAHS NTQYVDFSPC EQYLVTYGPN GQKIIIWDIR TGTEKRSFVS DGSSNMSMFR
WSHDDKYVAR MGDNAIHVYE TNTFYLLDKK SIKVQGIRNF SWSPTDNIIA YWMSEDIDAP
ARVTLLEIPK KIEVRNKNLF NVADCKIHWQ KSGDYLCVKV DRYSKSKKDK KDADVKFLGM
FYNFEIFHMR EKDIPVDSVE VKETILAFAW EPVGSKFSII HGEPSNANVS FYEAKKGQEP
TMLRKMEKKV CSHLFWSPRG QFIVLANLQM GSFEFVDTND FTIMKSGDHY RASEVEWDPT
GRYVVTGTSG KVKEDHGYHL WSFQGRILKR VNLKNFMLFL WRPRPPTLLP DERQKEIRKN
LKKYYAQFES KDRVRMTRAS KELLEKRAKL REQFVEYRAK RVNDWEEQKY RRMQLRNNMD
TDTLEADPDN VEEEIVEILV REDTTLLE
