EIF3B_DEBHA
ID EIF3B_DEBHA Reviewed; 719 AA.
AC Q6BLY5;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001};
GN OrderedLocusNames=DEHA2F09768g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; CR382138; CAG89127.2; -; Genomic_DNA.
DR RefSeq; XP_460786.2; XM_460786.1.
DR AlphaFoldDB; Q6BLY5; -.
DR SMR; Q6BLY5; -.
DR STRING; 4959.XP_460786.2; -.
DR PRIDE; Q6BLY5; -.
DR EnsemblFungi; CAG89127; CAG89127; DEHA2F09768g.
DR GeneID; 2904198; -.
DR KEGG; dha:DEHA2F09768g; -.
DR VEuPathDB; FungiDB:DEHA2F09768g; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_4_0_1; -.
DR InParanoid; Q6BLY5; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; RNA-binding; WD repeat.
FT CHAIN 1..719
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363818"
FT DOMAIN 41..128
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 194..233
FT /note="WD 1"
FT REPEAT 234..295
FT /note="WD 2"
FT REPEAT 305..343
FT /note="WD 3"
FT REPEAT 346..388
FT /note="WD 4"
FT REPEAT 456..501
FT /note="WD 5"
FT REPEAT 517..559
FT /note="WD 6"
FT REPEAT 573..618
FT /note="WD 7"
FT REGION 1..228
FT /note="Sufficient for interaction with PIC8"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REGION 1..102
FT /note="Sufficient for interaction with HCR1 and TIF32"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 719 AA; 82134 MW; 78BA6E17AAA9D88F CRC64;
MNDNMSEQEY RSLEKEVQLD DLDFSDLEAK YAVNSDFGMD NYVVVDGAPI APEAKVPILI
KVLKKLFNTV GEVVEGDEGI HMPLQDGKSK GYLFVQFKTP QMAEAAIQQL HGKKLDQKHR
LLVNKLSDIE KFGAEGNVEI DFHEPEIPPF KSHGYLRSWL QDEQGRDQMA LHFSETVGVY
YNKKKNDPEP VIEPRKGFTS KYAKFSPLGT YLFSVHPQGV QSWGGDGFQS ITKFIHNQVR
LIDFSPNEKY MVTLSPLPIA LPDDPAERSI FPFGPESNGH KLVIWDMATG EPARTFALPP
HLEGQKDMPW PLVKWSHDDK YCARQGPGAL AIYETPSFQL LDKKLVKVDD VVDFEWAPAA
VHLSDSKVKE GEYILSYWTP ESSNQTARVA LMQIPSRKVI RTINLFQVSD CKMHWHGEGK
FLCVKVDRHT KSRKTFFSNL EFFKVTEKDI PVEKLELKDV VFNFAWEPRS ERFITISRLD
DGNQNPSIAK NTISFYAPQV SSKGRVTSSK YTCFKEIHDK HSNTVCWSPK GRFVVVATIS
KSSGELEFYD CSYEEDKPAN SKVNGNVKLL KAEKYSGMTN LAWDPSGRFV AAWSSSWAHS
IENGYRLFEF TGNMLKDNSI DHFKEFIWRP RPASLLNAAD RKKVRKNLRE YSAQFDEADA
MEADAASREA ILLRRKLLEQ WRSYRAKHAA NGSKKNEVQA EIIEEIKEEI IEEKEEVVE
