EIF3B_DICDI
ID EIF3B_DICDI Reviewed; 670 AA.
AC Q54QW1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255|HAMAP-Rule:MF_03001};
GN Name=eif3B; Synonyms=eif3s9; ORFNames=DDB_G0283597;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; AAFI02000055; EAL65676.2; -; Genomic_DNA.
DR RefSeq; XP_639023.2; XM_633931.2.
DR AlphaFoldDB; Q54QW1; -.
DR SMR; Q54QW1; -.
DR STRING; 44689.DDB0233929; -.
DR PaxDb; Q54QW1; -.
DR EnsemblProtists; EAL65676; EAL65676; DDB_G0283597.
DR GeneID; 8624151; -.
DR KEGG; ddi:DDB_G0283597; -.
DR dictyBase; DDB_G0283597; eif3B.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_2_0_1; -.
DR InParanoid; Q54QW1; -.
DR OMA; NVADCKI; -.
DR PhylomeDB; Q54QW1; -.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DDI-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DDI-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:Q54QW1; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR GO; GO:0006413; P:translational initiation; ISS:dictyBase.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; RNA-binding; WD repeat.
FT CHAIN 1..670
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000330324"
FT DOMAIN 30..116
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 183..221
FT /note="WD 1"
FT REPEAT 222..269
FT /note="WD 2"
FT REPEAT 466..507
FT /note="WD 3"
FT REPEAT 509..553
FT /note="WD 4"
FT COILED 568..600
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 670 AA; 77520 MW; 62DB3FAA8C3ED742 CRC64;
MTIFDSDEEE LVTTLSDFEP PVQIDTSFNK FIVVDNIPVA PEAKHEKLKS ILVKIYQNRP
GAEVVGIHLA LDAQRNTKGF AFIEYSKKES AIDAATSLNN YPLDKSHTLK VNLLDDFSKF
ANFEETYKPP TREDFKPKPN YNQWLSDPKA LKGYDQFVTR YGDYTDICWN EMHVGKPMVE
KSSVSLTSSY VQWSNTGSYL VTFHPDGIAL YGGKDWIQVN LFEHRGVQLV DFSPEDKYLI
TFAPIASDNP NSPKSIVVWD VRSGKKLRSF LAPPKEQFTW PAFQWSAKDK YIARIEQLEK
GINIYETPSM NLLDDKIFEV KGIKDFSWSP TDLSLAYFVP ANDPLPAKIC LVEMPSKKLL
AEKSIWGATD ARFHWQNEGA YLCVKTDKVA TGKTKKEKIP TTSFELFRTH EPNVPIESFE
IQYAIKAFSW EPRGKRICII HGEFKMNMFV SFFEVQKTSV KLISKLENRK LNTIFWSPRG
TLVLLANLGD TGELEFYNTQ DCESYGTQEH LQCTGVDWNP SGRYVTTFVS HWKVQTDTGF
NIWSFNGDLV YSVLKDRFFQ FNWRPRPKFM LTNKEINQIK QNIKKYQEKF DKQDEDDNKA
IQHIEQTRLD NLMKEFLSFL QKGEQEYQAL EPTRKQLGSY EDIDPNDIYE SIETIEELID
IKTIVLKKIN
