EIF3B_DROAN
ID EIF3B_DROAN Reviewed; 686 AA.
AC B3ME25;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255|HAMAP-Rule:MF_03001};
GN Name=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
GN Synonyms=eIF3-S9 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=GF11342;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with
CC mxt (By similarity). {ECO:0000250|UniProtKB:Q0E940, ECO:0000255|HAMAP-
CC Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; CH902619; EDV37570.1; -; Genomic_DNA.
DR RefSeq; XP_001960748.1; XM_001960712.2.
DR AlphaFoldDB; B3ME25; -.
DR SMR; B3ME25; -.
DR STRING; 7217.FBpp0114534; -.
DR EnsemblMetazoa; FBtr0116042; FBpp0114534; FBgn0088382.
DR GeneID; 6494206; -.
DR KEGG; dan:6494206; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_1_0_1; -.
DR InParanoid; B3ME25; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR PhylomeDB; B3ME25; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030707; P:ovarian follicle cell development; IEA:EnsemblMetazoa.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; RNA-binding; WD repeat.
FT CHAIN 1..686
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363794"
FT DOMAIN 53..137
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 203..242
FT /note="WD 1"
FT REPEAT 289..327
FT /note="WD 2"
FT REPEAT 330..365
FT /note="WD 3"
FT REPEAT 438..480
FT /note="WD 4"
FT REPEAT 526..571
FT /note="WD 5"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 590..642
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 686 AA; 79774 MW; 82BB4A14A17B114C CRC64;
MAKKHAGADA NDSDYNEEPN FEDPPGFVDT ISDEDLLGDM LAQRPSEADG VESVVVVDNI
PKVEPVRLEK LKSVINKLFS HCGDIVNVVY PVDEEGKTKG YAFMEYKHAS QAEDAVKKLN
NHRLDKNHTF AVNLFTDFQK YENIPEKWEP PTIQTFKVQS DLYNFINDPD AYDQYCVAAE
TAPNCVQVGF WQNTLPEPSE LETRERFTDT FVKWSPLGTY VVTFHKPGVA IWGGSNFQKI
QKFPHPGTQF VEFSPCENYL VTYGPTPTGQ KIIIWDIRTG AEKRSFVADG MSVLSMFRWS
HDDKFVARMG ENSIHIYETP SFYLLDLKSI KIPGIRGFSW SPTDNVIAYW VEEQNQIPAR
VTLMEIPKKR EIRNKNLFHV ADCKLHWQKS GDYLCVKVDR YSKLKKDKKE LDVKFLGMFY
NFEIFHMREK EIPVDSVEIR ELILAFAWEP IGNKFSIIHG EPNSSNVSFY EVNKGVKPSL
VKRLEKKSCT HLFWSPRGQF IVMANLTMGT FEFVDSTNDY IISASPDHFR ASEVEWDPTG
RYVVTGVSSW KVKEDTGFNM YTFQGRIIKR TILKNFVQFL WRPRPPTLLA EEKQKEIKKN
LKKYYAVFEQ KDRLRLTRAS KELLEKRAQL RETFMEYRNK RIAEWKDQKS RRVMLRGHVD
TDNLETEEVD EEIVEFLVKE EITLLE
