EIF3B_MAGO7
ID EIF3B_MAGO7 Reviewed; 746 AA.
AC A4QZL9; G4MMB8;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=MGG_01978;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; CM001231; EHA56104.1; -; Genomic_DNA.
DR RefSeq; XP_003708716.1; XM_003708668.1.
DR AlphaFoldDB; A4QZL9; -.
DR SMR; A4QZL9; -.
DR STRING; 318829.MGG_01978T0; -.
DR EnsemblFungi; MGG_01978T0; MGG_01978T0; MGG_01978.
DR GeneID; 2681097; -.
DR KEGG; mgr:MGG_01978; -.
DR VEuPathDB; FungiDB:MGG_01978; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_4_0_1; -.
DR InParanoid; A4QZL9; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR Proteomes; UP000009058; Chromosome 1.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding; WD repeat.
FT CHAIN 1..746
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363821"
FT DOMAIN 42..128
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 195..234
FT /note="WD 1"
FT REPEAT 247..294
FT /note="WD 2"
FT REPEAT 307..346
FT /note="WD 3"
FT REPEAT 349..386
FT /note="WD 4"
FT REPEAT 458..500
FT /note="WD 5"
FT REPEAT 517..560
FT /note="WD 6"
FT REPEAT 575..620
FT /note="WD 7"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 85759 MW; 6EC70B567FECD6C9 CRC64;
MAPSYEHLRE ADLDEDEFDE DEVDVSDLRE KFEVQLEQGF DTFVVIDGLP EVTEEQKPKL
VKFLLKKLTS VGKTKEDMID MPMGPDGKSL RFAFVEYSSP GEAAAAVRQL DRVPLDKKHT
LRVNKLMDVD RFGREGRIDD EYQPPHIDEF HPRDHLRSFM ADPSGRGRDQ FVMFRGDHVG
VFWNNEKDTP ENIVDRPNWT ESFVQWSPLG TYLLSMHMQG VQLWGGPKWD RLGRFPHPFV
NMAAFSPQEN YLVTWSNRPI SIPDEGHPAL SMDDDGKNYV IWDIATGKPL RSFANLDLPP
DDPNKPPRKH PWPAFKWSSD DKYVARLTQG QSISVYELPR MNLLDKTTIK VEGVQDFEWA
PSRPQRDGVK TYEQMFCYWT PEIGSNPAKV GLMSIPSKEV VRSLNLFSVS DVKLHWQSEG
AYLCVKVDRH SKSKKSQATT LEIFRVKEKG VPVEVVDTIK DTVINFAWEP KGDRFLIITT
VTPTGEVAVQ PKTAISFFCP EKSKGSTVGN FKHLRTLDKR NSNAIYWSPK GRFVVVATVH
NQNSSDLDFF DLDFEGEKPE GEKDLTANLQ LMNTADHYGI TDVEWDPSGR FVATWASAWK
HTMENGYHMY DFKGEQLREE AVEKFKQLQW RPRPPTLLAK EEQKQIRKNL REYSRVFEQE
DAERIAGADQ EVVDNRRRIL EDWYEWRESV DVEVDEESAA MGVSSNPAEE LLKAKTAEIL
ASGQEEEQVI EEIVEEVLEE SEEIVS
