ID   EIF3B_NEUCR             Reviewed;         747 AA.
AC   Q7S464;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE            Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE   AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE            Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE   AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN   Name=prt-1; ORFNames=NCU02208;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC       Rule:MF_03001}.
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DR   EMBL; CM002242; EAA30291.1; -; Genomic_DNA.
DR   RefSeq; XP_959527.1; XM_954434.3.
DR   AlphaFoldDB; Q7S464; -.
DR   SMR; Q7S464; -.
DR   STRING; 5141.EFNCRP00000003266; -.
DR   EnsemblFungi; EAA30291; EAA30291; NCU02208.
DR   GeneID; 3875676; -.
DR   KEGG; ncr:NCU02208; -.
DR   VEuPathDB; FungiDB:NCU02208; -.
DR   HOGENOM; CLU_011152_4_0_1; -.
DR   InParanoid; Q7S464; -.
DR   OMA; NVADCKI; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR   GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   CDD; cd12278; RRM_eIF3B; 1.
DR   Gene3D; 2.130.10.10; -; 2.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03001; eIF3b; 1.
DR   InterPro; IPR011400; EIF3B.
DR   InterPro; IPR034363; eIF3B_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR14068; PTHR14068; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   PIRSF; PIRSF036424; eIF3b; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; RNA-binding; WD repeat.
FT   CHAIN           1..747
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   B"
FT                   /id="PRO_0000363823"
FT   DOMAIN          42..128
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT   REPEAT          195..234
FT                   /note="WD 1"
FT   REPEAT          236..292
FT                   /note="WD 2"
FT   REPEAT          310..349
FT                   /note="WD 3"
FT   REPEAT          520..563
FT                   /note="WD 4"
FT   REPEAT          578..623
FT                   /note="WD 5"
SQ   SEQUENCE   747 AA;  85566 MW;  7B4D6331EF83E91D CRC64;
     MAPSFDHLRD EDLDEDDFDV DEVDISDIRE KYEVQLEQGY DAFVVVDGLP EVNEEQKPKL
     VKFLLKKLNT VGKTREDLIF MPMGEDGKSL RFAFVEYSSP AEAAAACRQL DLVPLDKKHT
     LRVNKLTDVD RYGREGRIDD EYTPPKIEEF QEKEHLRSFM ADPSGRGRDQ FVMFRGESVG
     VFWNNEKDTP ENIVDRQHWT ETFVQWSPLG TYLTSVHAQG VQLWGGPSWT RQRRFAHPFV
     NLVAFSPNEK YLVTWSNRPI SIPEEGHPAL SVEDDGKNYV IWDIETSKPL RSFAQLDTPA
     AAEGEAPKKA PKFPWPAFKW SADDKYVARL NPGQSISVYE LPRMNLLDKT AIKIEGVVDF
     DWAPATVQRD GVKSYEQLFC FWTPEIGSNP ARVGLMSIPS KQVVRSLNLF SVSDAKLHWQ
     SEGAYLCVKV DRHSKSKKSQ ATTLEIFRVK EKGVPVEVVD TIKDTVINFA WEPKGDRFVI
     ITTTEPVGAT AVPPKTSVAF FCPEKAKGNA VGNFKHLRTL EKKNSNAIYW SPKGRFVVVA
     TVANTQSSDL DFYDLDFEGE KPESDKDLTA NLQLMNTADH YGVTDVEWDP SGRFVATWAS
     AWKHSMENGY HLYDFKGEQL REEAIEKFKQ FQWRPRPATL LSKEEQKAIR RNLREYSRIF
     EQEDAERISS ADVAVVEARR RLLEEWFAWR EAIRQEVAEE REIYGLPADP VADLIKAKTP
     ELATDQEEQV IEEIMEEVLE ETEEIVQ