EIF3B_PICAN
ID EIF3B_PICAN Reviewed; 220 AA.
AC P12806;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B;
DE Short=eIF3b;
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog;
DE Short=eIF3 p90;
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
DE Flags: Fragment;
GN Name=TIF32; Synonyms=PRT1;
OS Pichia angusta (Yeast) (Hansenula polymorpha).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Ogataea.
OX NCBI_TaxID=870730;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL
RC Y-5445;
RX PubMed=2500147; DOI=10.1016/0167-4781(80)90003-2;
RA Bruinenberg P.G., Evers M., Waterham H.R., Kuipers J., Arnberg A.C., Ab G.;
RT "Cloning and sequencing of the peroxisomal amine oxidase gene from
RT Hansenula polymorpha.";
RL Biochim. Biophys. Acta 1008:157-167(1989).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000250|UniProtKB:P55884}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000250|UniProtKB:P55884}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P55884}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000305}.
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DR EMBL; X15111; CAA33208.1; -; Genomic_DNA.
DR PIR; S16511; S16511.
DR AlphaFoldDB; P12806; -.
DR SMR; P12806; -.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; RNA-binding.
FT CHAIN 1..220
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000123536"
FT DOMAIN 37..120
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..220
FT /note="Sufficient for interaction with PIC8"
FT /evidence="ECO:0000250"
FT REGION 1..94
FT /note="Sufficient for interaction with HCR1 and TIF32"
FT /evidence="ECO:0000250"
FT NON_TER 220
SQ SEQUENCE 220 AA; 24962 MW; D317E7EFF49834B5 CRC64;
MPEPIAFDES QVDISSIDFS DLEAKYHVPE PEHSYEHFVI CDGAPIAPEA KAPVLKKVLT
KLFSQCGKVV DMFMPLENGQ TKGFLIIELD SAAAADKAVK QLNGKKLDVK HRLAVNKLPD
MEKYALNDNI SEEFREPAIP EFRSHGYLKS WLLDPNGREQ FMLHHHDTVG VYWYKKNIQP
EEVIEPRAHW TSASMKFSPK GTYLFSFFPG GVQAWGGERI
