EIF3B_PICGU
ID EIF3B_PICGU Reviewed; 738 AA.
AC A5DR43;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3, p90 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=PGUG_05744;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; CH408162; EDK41646.2; -; Genomic_DNA.
DR RefSeq; XP_001481981.1; XM_001481931.1.
DR AlphaFoldDB; A5DR43; -.
DR SMR; A5DR43; -.
DR STRING; 4929.XP_001481981.1; -.
DR EnsemblFungi; EDK41646; EDK41646; PGUG_05744.
DR GeneID; 5123881; -.
DR KEGG; pgu:PGUG_05744; -.
DR VEuPathDB; FungiDB:PGUG_05744; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_4_0_1; -.
DR InParanoid; A5DR43; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding; WD repeat.
FT CHAIN 1..738
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000366877"
FT DOMAIN 59..146
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 211..250
FT /note="WD 1"
FT REPEAT 322..360
FT /note="WD 2"
FT REPEAT 363..406
FT /note="WD 3"
FT REPEAT 537..579
FT /note="WD 4"
FT REGION 1..245
FT /note="Sufficient for interaction with PIC8"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REGION 1..120
FT /note="Sufficient for interaction with HCR1 and TIF32"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 738 AA; 84213 MW; 6A9491957EC76AA7 CRC64;
MCGCVGVISN VDENFQVKTI VTMSDIDYEA LEKEVPLDDI DFSDLEEQYA VKPDFGIDNF
VVVDGAPIAP EAKVPVLIKV LKKLFSTVGE IVEGEEGIHM PLEDGKSKGF LFIQFKTAQM
ADAAIQQMHG KKLDQKHRLL VNKLSDIEKY GIEGNVPTEF KEPEIPPFKS HGYLKSWLQD
EQGRDQIGLH YSDTFGVYWN KRKSPEPVIE PRKGFTSKYA KFSPKGTYLF SIHPQGIQSW
GGAQFESISK FIHSQVRLID FSPNEKYLVT LSPQPIQVPE NPAERASYPF GPESNGHKLV
IWDLATSEPA RTFALPPHLE GQKEMPWPLV KWSHDDKYCA RQGPGALAIY ETPSFQLLDK
KLVKIDDIVD FEWAPAPVYL DTSSQNGPGE HVLSYWTPES SNQTARVALM QIPSRQVLRT
INLFQVSDCK MHWQDEAKYL CVKVDRHTKS GKTIFSNLEF FKVTERDIPV EKLELKEVVI
NFAWEPRSDR FVTISRLDDG ALNPAIPKNT IAFYAPETSK TKGGAITSSK YKAFETVVDK
HSNTVYWSPK GRFVVIATLA RSNGELEFYD CTYEEENVRT TSKNNVKLLK SEKFSGMTNL
AWDPSGRFVA AWSSSWIHTI ENGYKMFEFT GNMLRDESID NFNEFLWRPR PPSMLNAADR
KKVRKNLRTY SAQFEEADAM EADAATRQLI LTRRKQLEEW RAYRAKHASA GHQKKEDKMT
VIEEIKEEII EEKEEIVE
