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EIF3B_PICST
ID   EIF3B_PICST             Reviewed;         712 AA.
AC   A3LY29;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE            Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE   AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE            Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE   AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN   Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=PICST_73391;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC       Rule:MF_03001}.
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DR   EMBL; CP000500; ABN67905.1; -; Genomic_DNA.
DR   RefSeq; XP_001385934.1; XM_001385897.1.
DR   AlphaFoldDB; A3LY29; -.
DR   SMR; A3LY29; -.
DR   STRING; 4924.XP_001385934.1; -.
DR   EnsemblFungi; ABN67905; ABN67905; PICST_73391.
DR   GeneID; 4839799; -.
DR   KEGG; pic:PICST_73391; -.
DR   eggNOG; KOG2314; Eukaryota.
DR   HOGENOM; CLU_011152_4_0_1; -.
DR   InParanoid; A3LY29; -.
DR   OMA; NVADCKI; -.
DR   OrthoDB; 1194797at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd12278; RRM_eIF3B; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03001; eIF3b; 1.
DR   InterPro; IPR011400; EIF3B.
DR   InterPro; IPR034363; eIF3B_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR14068; PTHR14068; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF036424; eIF3b; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; RNA-binding; WD repeat.
FT   CHAIN           1..712
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   B"
FT                   /id="PRO_0000363824"
FT   DOMAIN          37..124
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT   REPEAT          191..229
FT                   /note="WD 1"
FT   REPEAT          230..293
FT                   /note="WD 2"
FT   REPEAT          301..339
FT                   /note="WD 3"
FT   REPEAT          342..384
FT                   /note="WD 4"
FT   REPEAT          452..493
FT                   /note="WD 5"
FT   REPEAT          513..555
FT                   /note="WD 6"
FT   REPEAT          566..604
FT                   /note="WD 7"
FT   REGION          1..224
FT                   /note="Sufficient for interaction with PIC8"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT   REGION          1..98
FT                   /note="Sufficient for interaction with HCR1 and TIF32"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ   SEQUENCE   712 AA;  81224 MW;  8E1CA303E6F4D5D0 CRC64;
     MSLTEAEYHE LEKQVNLDDI DFSDLEEQYE VDVGLDNYVV VDGAPIAPEA KVPVLIKVLK
     KLFNTVGKVV EGDEGIYMPL EDGKSKGYLF VQFETSEMAE AAIKQLHGKK LDQKHRLLVN
     RLSDIEKYGV EGNVAAEFVE PELPPFKSHG YLKSWLQDPQ GRDQIALHHS ETFGVFWNKK
     KSDPEPVFEP RKFFTSKYAK FSPKGTYLFS IHPQGVQSWG GADFSSIDKF MHNQVRLVDF
     SPNEKYMVTL SPLPITAPDS AAERAVFPFG PESYGHKLVI WDLTTGEPAR TFALPPHLEG
     QKEMPWPLVK WSHDDKYCAR QGPGALAVYE TPSFQLLDKK LIKIDDIVDF EWAPAGVHLA
     NNKSENGHHL LSYWTPESSN QTARVAVMQI PTRQILRTVN LFQVSDCKMH WQSEGKLLCV
     KVDRHTKSGK TIFTNLEFFK TTEKDIPVEK LELKEIVINF AWEPKSERFV IISRLDDGNL
     NSAIPKNIID FYAPDVNGKG KSATSVYKSY KTITDKHSNT VFWSPKGRYV VVATISRSNG
     EIEFFDVSFD DSNKNAPANV KLLKNDKFSG MTNISWDPSG RFVATWSSSW LHTIENGYKL
     YEFTGNLLRD DSIDQFKEFI WRPRPASLLN SADRKKVRAN LREYSAQFEE SDAMEADAAL
     RELIYARRRA LEDWKAYRAK HASKAVKANE VQAEIIEEIK EEIIEEKEEI VE
 
 
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