EIF3B_USTMA
ID EIF3B_USTMA Reviewed; 745 AA.
AC Q4P6G4; A0A0D1DZ20;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=UMAG_04299;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM003151; KIS67805.1; -; Genomic_DNA.
DR RefSeq; XP_011390752.1; XM_011392450.1.
DR AlphaFoldDB; Q4P6G4; -.
DR SMR; Q4P6G4; -.
DR STRING; 5270.UM04299P0; -.
DR PRIDE; Q4P6G4; -.
DR EnsemblFungi; KIS67805; KIS67805; UMAG_04299.
DR GeneID; 23564523; -.
DR KEGG; uma:UMAG_04299; -.
DR VEuPathDB; FungiDB:UMAG_04299; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_4_0_1; -.
DR InParanoid; Q4P6G4; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR Proteomes; UP000000561; Chromosome 12.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; RNA-binding; WD repeat.
FT CHAIN 1..745
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363825"
FT DOMAIN 41..129
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 189..230
FT /note="WD 1"
FT REPEAT 251..293
FT /note="WD 2"
FT REPEAT 303..344
FT /note="WD 3"
FT REPEAT 580..625
FT /note="WD 4"
FT COILED 644..745
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 745 AA; 86022 MW; 95E558C592574D20 CRC64;
MPSVDEITNG VDELDFVDDA DIDFSDIEQK YSVKFDEGLD DVIVIEGVPV ITESRQQKLF
ETIQKRFKTH ANIDIAVEGM HIPYADNGES KGYIFVEMAS AEDAAQAIRQ MDGYAFDKKH
RFSVHRFTDV EKFASLSETY EEPQEEEFKP REHLRSWLAD PAGRDQLVIC RGDDVEIAWH
NRSSDPQVEH SRPRWTESYV QWSPLGTFLT TFHRQGIQIW GGPSCERFMR FPHPGARLVD
FSPSEKYMVT WSHEPIQVPD NAPIGPQFFG PEDEGNRIAV WEVRTGHLLR SFPVPQDESG
QPGQLKGFSW PFLKWSPDDK YCARLNPGQA ISVYETPSMG LLEKKSIKIE GVVDFEWCPM
GDKDRELAEA AKPNKKARDN MIVYWQPEVA NQPARVTVMA VPSRTILRSK NLFNVSDCKL
HWHPQGDYLC VKVDRHTKTK KSMFCNLEIF RVREKEFPVE VVELKDAVTA FAWEPFGTHF
ALISSNDPQL GTPASGITIK TQLNFYHLHP KGDFRPLKVF DNKTANTLFW SPRGRHIVVA
TLGSSQKFDL EWYDVDFMHE VRQGNPSADP ADDVKLIGTG EHYGITDLEW DPSGRYVATS
ASVWRHSLEN GFAIWDFKGQ ELQKHIQDRF KQILWRPRPR TLLGKDEQKR VRKNLREYSK
QFEEEDAAEE SNLASAEREL YQRILEEWKA WRARSRRDLE QLRADLGREE VGQSVDHAKK
LAEEATEEVQ EWMEEIIEET EEVLA
