EIF3B_VANPO
ID EIF3B_VANPO Reviewed; 726 AA.
AC A7TKF2;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 90 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3 p90 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Translation initiation factor eIF3 p90 subunit homolog;
GN Name=PRT1 {ECO:0000255|HAMAP-Rule:MF_03001}; ORFNames=Kpol_538p39;
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC Y-8283 / UCD 57-17;
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; DS480407; EDO17279.1; -; Genomic_DNA.
DR RefSeq; XP_001645137.1; XM_001645087.1.
DR AlphaFoldDB; A7TKF2; -.
DR SMR; A7TKF2; -.
DR STRING; 436907.A7TKF2; -.
DR EnsemblFungi; EDO17279; EDO17279; Kpol_538p39.
DR GeneID; 5545485; -.
DR KEGG; vpo:Kpol_538p39; -.
DR eggNOG; KOG2314; Eukaryota.
DR HOGENOM; CLU_011152_4_0_1; -.
DR InParanoid; A7TKF2; -.
DR OMA; NVADCKI; -.
DR OrthoDB; 1194797at2759; -.
DR PhylomeDB; A7TKF2; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; RNA-binding; WD repeat.
FT CHAIN 1..726
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363826"
FT DOMAIN 37..120
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 142..182
FT /note="WD 1"
FT REPEAT 186..224
FT /note="WD 2"
FT REPEAT 235..283
FT /note="WD 3"
FT REPEAT 331..374
FT /note="WD 4"
FT REPEAT 442..485
FT /note="WD 5"
FT REPEAT 505..549
FT /note="WD 6"
FT REPEAT 566..611
FT /note="WD 7"
FT REGION 1..219
FT /note="Sufficient for interaction with PIC8"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REGION 1..94
FT /note="Sufficient for interaction with HCR1 and TIF32"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
SQ SEQUENCE 726 AA; 82947 MW; C2EBEB12F43ABE28 CRC64;
MSAALEDIKL EDIPVDDIDF SDLEKQYSVN DTVSFDQYIV VCGAPVIPEG KVAVLKKALT
GLFSKAGKVV DIEFPIEDGK TKGFLFVECA SPADGNKIIK AFHTKRLDLK HRLFIYTMRD
VEKYNDKNFP TEFVEPEIPD FFPTSTLKSW LSDEDGRDQF VLQANEMTTV LWNSAIEDEE
SVVESRKNWS TNYIRFSPKG TYLFSYHPQG VVMWGGPHFD RLRRFYHPNV RTSSVSPSEK
FLVTYSPDPI VVDEEDADCP FTKKNEGHQL CIWDIDSGLL QSTFPVVKSS YLQWPLVRWS
YNDQYCARMV GETLVVHDVK KGFAVMDNKT LKVPGIRDFS FAPTGVKIAP FRANDKESVI
LAYWTPETNN MSCKATIVDV ERSRVLKTVN LVQVSNVTLH WQSDSEFLCF NVERHTKSKK
TQFSNLEICK LTEKDIPGDK IELKDCVVDF AWEPHGNRFG VIAVRETGDD NIAIPKNVAT
FFAPEKRDVK DKSTGVKKWL EVASITDKFS NTISWSPAGR YVVVATLVKP NVRRSDFVFY
DMDFATDKNM NVTKDVHASL KEVATNSFPS ATDMAWDPSG RFLAVWSSSL KHKMENGYKV
FNVAGTIVKE EPLNSFKNFA WRPRPASLLT NAEKKKIRKN LKEWTAQFAE QDAMEADAAT
RDMILRQREM LKDWTEYRAE IGARFEEEFG YKTFNMIPLS NSEDDFTSVE EVKEEVLEES
EEKVVE
