EIF3B_XENLA
ID EIF3B_XENLA Reviewed; 688 AA.
AC Q569Z1;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit B {ECO:0000255|HAMAP-Rule:MF_03001};
DE Short=eIF3b {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 9 {ECO:0000255|HAMAP-Rule:MF_03001};
DE AltName: Full=eIF-3-eta {ECO:0000255|HAMAP-Rule:MF_03001};
GN Name=eif3b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC eif3m. {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit B family. {ECO:0000255|HAMAP-
CC Rule:MF_03001}.
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DR EMBL; BC092246; AAH92246.1; -; mRNA.
DR RefSeq; NP_001090004.1; NM_001096535.1.
DR AlphaFoldDB; Q569Z1; -.
DR SMR; Q569Z1; -.
DR BioGRID; 592856; 2.
DR IntAct; Q569Z1; 1.
DR DNASU; 735075; -.
DR GeneID; 735075; -.
DR KEGG; xla:735075; -.
DR CTD; 735075; -.
DR Xenbase; XB-GENE-963855; eif3b.L.
DR OrthoDB; 1194797at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 735075; Expressed in lung and 19 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR CDD; cd12278; RRM_eIF3B; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR Gene3D; 3.30.70.330; -; 1.
DR HAMAP; MF_03001; eIF3b; 1.
DR InterPro; IPR011400; EIF3B.
DR InterPro; IPR034363; eIF3B_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR14068; PTHR14068; 1.
DR Pfam; PF08662; eIF2A; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF036424; eIF3b; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; RNA-binding; WD repeat.
FT CHAIN 1..688
FT /note="Eukaryotic translation initiation factor 3 subunit
FT B"
FT /id="PRO_0000363787"
FT DOMAIN 61..144
FT /note="RRM"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT REPEAT 164..206
FT /note="WD 1"
FT REPEAT 208..246
FT /note="WD 2"
FT REPEAT 248..293
FT /note="WD 3"
FT REPEAT 297..335
FT /note="WD 4"
FT REPEAT 338..373
FT /note="WD 5"
FT REPEAT 436..492
FT /note="WD 6"
FT REPEAT 525..570
FT /note="WD 7"
FT REPEAT 635..680
FT /note="WD 8"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 589..640
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03001"
FT COMPBIAS 9..43
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 80256 MW; 9BA7F810CBC4134D CRC64;
MLESERPERD MEEEGEESNE EEEEEGMSFS DPEGFEDDIS DEELLGDILK DRPQEADGID
SVIVVDNVPQ VGPDRLEKLK NVIVKIFSKF GKLTNEFYPQ AEGSTKGYIF LEYALPAQAQ
DAVKNADGYK LDKQHTFRVN LFTDFDKYMV IGDEWDVPEK QPFKDFGNLR SWLEDPDCRD
QFSVIYESGD RTSIFWTDVK EPVPVEERAR WTETYVRWSP KGTYLATFHQ RGIALWGGEK
FKQIQRFSHQ GVQLIDFSPC ERYLVTFSPL MDTKEEPQAI IIWDILTGHN KRGFHCESSA
HWPIFKWSHD GKFFARMTLD TLSIYETPSM GLLDKKSLKI TGIKDFSWSP GGNIIAFWVP
EDKDIPARVT LMQMPTRQEI RVRNLFNVVD CKLHWQKNGD YLCVKVDRTP KGTQGMVTNF
EIFRMREKQV PVDVVEMKDG IIAFAWEPNG SKFAVLHGEV PRISVSFYHV KNNGKIELIK
MYDKQQANTI FWSPQGQFLV LAGLRSMNGA LAFVDTSDCT IMNIAEHYTA SDVEWDPTGR
YVITSVSWWS HKVDNAYWMW TFQGRLLQKN NKDRFCQLLW RPRPPSLLSQ DQIKQIKKDL
KKYSKIFEQK DRLSQTKASK ELIERRRAMM EEYKTYREMA TKLYMEQKTA RLEIRGGVDT
DLLDSNVEDW EEETIEFFVT EEIIPVEE
