EIF3C_ANOGA
ID EIF3C_ANOGA Reviewed; 955 AA.
AC Q7PMU8;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=eIF3-S8 {ECO:0000255|HAMAP-Rule:MF_03002}; ORFNames=AGAP004725;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; AAAB01008968; EAA13192.4; -; Genomic_DNA.
DR RefSeq; XP_318103.3; XM_318103.4.
DR AlphaFoldDB; Q7PMU8; -.
DR SMR; Q7PMU8; -.
DR STRING; 7165.AGAP004725-PA; -.
DR PaxDb; Q7PMU8; -.
DR PRIDE; Q7PMU8; -.
DR GeneID; 1278503; -.
DR KEGG; aga:AgaP_AGAP004725; -.
DR CTD; 1278503; -.
DR VEuPathDB; VectorBase:AGAP004725; -.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_0_1; -.
DR InParanoid; Q7PMU8; -.
DR OMA; VVMHRSE; -.
DR OrthoDB; 273138at2759; -.
DR PhylomeDB; Q7PMU8; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..955
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000365382"
FT DOMAIN 658..834
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..178
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 111573 MW; 78925E500E0B2698 CRC64;
MSRFFAGGSD SDSDSSSDSE PVIRQQVAQF TFSDEEEDVK RVVRSKKEKR YEDLSNIIKS
IRNHKKIKDM SSVLTSFEEF MRAYTKALPV VMKEENGVTP RIVVRALAEL EDFVNESWDD
KESRKNLSKN NNKALGTLRQ KFRKYIKDFE SDMKRFRAAP EDFAEEEEDD EREDEKGSDE
EEEKVVVQVE PKAVSFKKEP EKAKPVKPVA DSDSSDWGSD SDSDSTSSDE DAKYTSIRDR
FLKKPEKGTE EIASAPSGVS GDDAFKKEKK KKTGEALSKK KKPKQDEMFD ENEEEEEGWK
VVNGTRSGAS EQPKMFAKDA EIDTKLVVNK LNEVMAARGK KRTDRKMQIE FLRELRTVAE
TNNLGPAVAV KIRFNIVSAI FDYNPKVSGA MKLEHWSKLL EEIQELLKLL LAHEDVHLSE
SILDEYEEYD TAPFKIRGCM LTAVERLDDE FTKLLKECDP HSNEYVDRLK DEVPVTNIIE
QVVTYVERLG NEMEICRIYL RKIDHLYYKF DPDVLKKRKG QLPANTITSV EEMDKLCRYI
YAKDQTDRLR TRAILSHIFH HALHDNWFQA RDLVLMSHLQ ETIHHSDPAT QILYNRMMAN
LGLCAFRHGN IKDAHLCLVD LMMTGKPKEL LAQGLVPQRQ HERSLEQEKI EKQRQMPFHM
HINLELLECV YLVSAMLLEI PYMAAHEFDA RRRMISKTFY QQLRSSERQS LVGPPESMRE
HVVAAAKAMR HGDWNACANF IVNKKMNVKV WDLFYEANRV REMMIKFIKE ESLRTYLFTY
SNVFASISVP HLADMFKLPK SKVHSLISKM IINEELMASL DDPTETIVMH RSEPSRLQAL
SMQLADKVTN LVDANERIFE MKQGNFFQRG GNQGYNRDRQ NYRNQNQNQN WNNNRRQDNR
NRGNRGNQNR GEGREQREHH RDHHRDQREH REHQNREFRE QREQMRNVEY QNKAE
