ID   EIF3C_ASPOR             Reviewed;         861 AA.
AC   Q2U0Q9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE            Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE   AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE            Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE   AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN   Name=nip1; ORFNames=AO090011000340;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC       Rule:MF_03002}.
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DR   EMBL; AP007171; BAE64856.1; -; Genomic_DNA.
DR   RefSeq; XP_001825989.1; XM_001825937.2.
DR   AlphaFoldDB; Q2U0Q9; -.
DR   SMR; Q2U0Q9; -.
DR   STRING; 510516.Q2U0Q9; -.
DR   EnsemblFungi; BAE64856; BAE64856; AO090011000340.
DR   GeneID; 5998092; -.
DR   KEGG; aor:AO090011000340; -.
DR   VEuPathDB; FungiDB:AO090011000340; -.
DR   HOGENOM; CLU_004304_0_2_1; -.
DR   OMA; VVMHRSE; -.
DR   Proteomes; UP000006564; Chromosome 7.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR   GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:EnsemblFungi.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_03002; eIF3c; 1.
DR   InterPro; IPR027516; EIF3C.
DR   InterPro; IPR008905; EIF3C_N_dom.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13937; PTHR13937; 1.
DR   Pfam; PF05470; eIF-3c_N; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..861
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   C"
FT                   /id="PRO_0000364276"
FT   DOMAIN          599..773
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          812..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..51
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   861 AA;  97165 MW;  DA1BCA41998A850F CRC64;
     MSRFFYGSGS DSDSSSDEEE LLTDREEEEK SEEESSEEEE ETSEEESSDD EGETGANRFL
     RDASESEESE DEEKVTVVKS AKDKRLEELE GIIKLIENAE KINDWAVISS EFDKLNRQVV
     KVTQSGPVPR IYVKAVADLE DFVNETITKQ KSAKKMNASN SRGFNAVKQR IKKNNKEYAT
     HIEKYRSDKD GYMEGKEEEA KPAIVAPRLT KVERVVEAPA AATSTDDGFA TVGRGGKTLQ
     YTPESILKHL RVIVESRGKK NTDRLEQIKT MEKLLEVAQT PYQRIRVYLT LLSTRFDISS
     TSSANYMSVD QWKLAEKELA ALLSVLETNR DHVVTEGAEE WEDDEKQPQV KPGETLHIPG
     SIVSHVERLD DELTRSLQHI DPHTAEYIDR LSDEKQLYTN LVRVQAYIEG LVEAEKSDMR
     QDSLNRVVMR RLEHIYFKPS QVVTILEEGT WKALPSELDS KVTPRGNAGD VTGLVQTLCN
     YLFTYSDGII RARAMLCQIY FLALHDQYYR SRDLMLMSHL TENISNFDVN TQILFNRTLV
     QIGLCAFRAG LIYEAQNTLS EVCGSGRQKE LLAQGIILQR YSTVSPEQER LERQRQLPFH
     MHINLELLEC IYLTSSMFLE VPLMAQTSSS PELKRRIISK TFRRMLDYNE RQVFTGPAEN
     TRDGVIMSAK FLAAGDWKKA AEMLNSIKIW DLMPQPDKIK EMLSQQIQEE GLRTYLFTYA
     PFYDSLSIST LSNMFELSEK KIAAIISRMI SHEELAAALD QVNDAIVFRK GVELSRLQSQ
     VVTLADKSMN LLEANEKTLE QRTQGMANAF QRDQGAGARG GRGPGRGGQA RGGPRLPGGQ
     QGRRPGGQQF SGGALGGAIK A