EIF3C_ASPTN
ID EIF3C_ASPTN Reviewed; 864 AA.
AC Q0CVT0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=nip1; ORFNames=ATEG_02204;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; CH476596; EAU37166.1; -; Genomic_DNA.
DR RefSeq; XP_001211382.1; XM_001211382.1.
DR AlphaFoldDB; Q0CVT0; -.
DR SMR; Q0CVT0; -.
DR STRING; 341663.Q0CVT0; -.
DR EnsemblFungi; EAU37166; EAU37166; ATEG_02204.
DR GeneID; 4316925; -.
DR VEuPathDB; FungiDB:ATEG_02204; -.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_2_1; -.
DR OMA; VVMHRSE; -.
DR OrthoDB; 273138at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:EnsemblFungi.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..864
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000364277"
FT DOMAIN 602..776
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..51
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 97317 MW; D59B6A138A64DAA2 CRC64;
MSRFFARGGS DSESSSEDEQ ELYSDREEEE QFSDSEEESS EAESSEEESS DDEGAGASRF
LKNVSESEES EDEERVTVVK SAKDKRLDEL EGIIKAIENA EKINDWAVIS SEFDKLNRQI
VKVTQAGPTP KIYIQTVADL EDFVNETIAK QKSSNKKMNA SNAKGFNAVK QRIKKNNKEY
ATLIEKYRAD KDGFMAGGDE EPKPVISAPR ISKVERVEAP VAVTATADDD GFATVGRGGK
TLQYTPESIL KHLRVIVESR GKKNTDRFEQ IRTMEKLLEV AQNPYQRIRI YLTLISTRFD
LTSSSSANYM SVDQWKLAQQ EFSTLLSVLE SNREYVVTEG AEEWEDDEKQ PQVAAGETLH
VPGSIVSYVE RLDDELTRSL QQIDPHTAEY IERLSDEKEL YTNLVRTQVY AEALTTSEKS
DPRQDSLNRV IMRRLEHIYF KPAQVVTILE EGTWKSLPSN LASDITPRAN SGEVTSLVQT
LCNYLFRHSD GILRARAMLC QIYFLALHDQ YYRSRDLMLM SHLTENIANF DVSTQILFNR
TLVQIGLCAF RAGLVYEAQN TLSEVCGSGR QKELLAQGII LQRYSTVSPE QERLERQRQL
PFHMHINLEL LECIYLTSSM FLEVPLMAQT SSSPEMKRRV ISKTFRRMLD YNERQVFTGP
AENTRDGVIM SAKFLAAGDW KKAAEMLNSI KIWDLMPQPE KIKEMLSQQI QEEGLRTYLF
TYAPFYDSVS IATLSNMFEL PEKKIQAIIS RMISHEELAA ALDQVNNAIV FRKGVELSRL
QSQIVTLADK SMNLLEANEK TLEQRTQGMA NAFQRDQGAG ARGGRGAGRG GQARGGPRFP
GGQQGRRPGG QQFSGGALGG AIKA
