EIF3C_CANAL
ID EIF3C_CANAL Reviewed; 874 AA.
AC Q5AML1; A0A1D8PLB2;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=NIP1 {ECO:0000255|HAMAP-Rule:MF_03002};
GN OrderedLocusNames=CAALFM_C401490WA; ORFNames=CaO19.12105, CaO19.4635;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; CP017626; AOW28930.1; -; Genomic_DNA.
DR RefSeq; XP_722707.2; XM_717614.2.
DR AlphaFoldDB; Q5AML1; -.
DR SMR; Q5AML1; -.
DR BioGRID; 1218529; 2.
DR STRING; 237561.Q5AML1; -.
DR PRIDE; Q5AML1; -.
DR GeneID; 3635618; -.
DR KEGG; cal:CAALFM_C401490WA; -.
DR CGD; CAL0000176830; NIP1.
DR VEuPathDB; FungiDB:C4_01490W_A; -.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_2_1; -.
DR InParanoid; Q5AML1; -.
DR OrthoDB; 273138at2759; -.
DR PRO; PR:Q5AML1; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 2.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..874
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000364278"
FT DOMAIN 598..774
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..58
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 99816 MW; 3F48F743656D53B2 CRC64;
MSRFFVSGYT SDSSSEEEDL LSTSEEELLS SSDEGEDNES DSSFFGEDDD ESEESSSDDE
DGRPSGPAYF LKKSFLKGAG GDDSDSDSDD EGRKVVKSAK DKLLDDMKSS IEIINSNKYN
NNWSIVLGEF DKFGRFLIRC NQTNLGTPKF YIKLLTSLDN SITETSNNER DDKTLKADEA
RAFNTLRQRI KKQIREFQVY YDLYKENPEE FDENEDEPLE SVQAGLNDNV KNEADNSNVG
ALASNRVLSP IFHTLKTISE SRGKKNIDKL EQIATLEKLL EANVSKSSPF ELISIYQMLL
SVRFDASSNQ AFMPLEQWQK NEQDLGKLLD LLEANVDTYQ VSELGSTTDD IDIEPVANAQ
GVKVIFGSIT SSIDRLDDEL TKSLQHTDPH STEYVERLKD ESTIYNLIVR GQAYVESITP
EDVKYKSEQL ARIVLRRLEH IYYKPKQLIK ANEEEAWRNI EYNSSIVSKG SSVDEVIDQL
TEFLQKQQKN KTYGKHAILF SIYYYAVNSQ YEKAKELFLR SQFYSNINSA ESSLQVQYNR
ALVQLGLSAF RAGSIEESHK ILNEIVNSQR SKELLGQGFN SKFPNQATVL ERQKLLPFHQ
HINLELLECV FMTCSLLIEI PTLAAIANNH KDSKRKNASL KSFKSKLDFH DRQFFTGPPE
SIKDHIVHAS IALQKGDWLK SYNLLSSIKI WKLFPDNDKL LAMMKNQLQI EGLRTYIFTY
KSVFKKLSIE KLQQIFQLSK DEVVSILEKM ITTGNVSGGE IIDNKFISFT STTEPQRSKL
QELAIVLNEK IQLLTEKNEK TQSNGYGKKQ QNKDQQNQQQ QNQNQNQQQQ QNQQQQQQQQ
SSQQQSNNIL SEESANKFRY ANVNSNNDEF QATA
