ID   EIF3C_COCIM             Reviewed;         860 AA.
AC   Q1DP77; A0A0D6K9N1; J3K513;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE            Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE   AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE            Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE   AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN   Name=NIP1 {ECO:0000255|HAMAP-Rule:MF_03002}; ORFNames=CIMG_07886;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC       Rule:MF_03002}.
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DR   EMBL; GG704913; EAS29140.1; -; Genomic_DNA.
DR   RefSeq; XP_001240723.1; XM_001240722.2.
DR   AlphaFoldDB; Q1DP77; -.
DR   SMR; Q1DP77; -.
DR   STRING; 246410.Q1DP77; -.
DR   PRIDE; Q1DP77; -.
DR   EnsemblFungi; EAS29140; EAS29140; CIMG_07886.
DR   GeneID; 4559798; -.
DR   KEGG; cim:CIMG_07886; -.
DR   VEuPathDB; FungiDB:CIMG_07886; -.
DR   InParanoid; Q1DP77; -.
DR   OMA; VVMHRSE; -.
DR   OrthoDB; 273138at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_03002; eIF3c; 1.
DR   InterPro; IPR027516; EIF3C.
DR   InterPro; IPR008905; EIF3C_N_dom.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13937; PTHR13937; 1.
DR   Pfam; PF05470; eIF-3c_N; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..860
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   C"
FT                   /id="PRO_0000364281"
FT   DOMAIN          598..772
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..51
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   860 AA;  97624 MW;  F76BE7C38EE68B9B CRC64;
     MSSRFFHGGS DSESSSSDEE ELYSDRDEEE VSDEEEETTS EEESSEEESD DEAGLTGAKQ
     YLRGAADLDE SDEEEDRVTI VKSAKDKRLE ELEGTMKLIE NAEKINDWAV ISTEFDKLNR
     QVAKIIQAGP TPKIYIKAIA DLEDFVNETV VKQKTTTKKM NASNAKGFNT VKQRIKKNNK
     DYTAEIEKYR ENKDEYLEEE EEQETVIVEK KARTIRIEDT LAQSDEGFST VGRGGRTLQY
     TPESILKHLR VIVESRGKKN TDRIEQIKVM EKLLEVASSP YHTIRILLTL ISTRFDLATS
     SLSNYMSTEQ WKLAENEIST LISTLEEHPQ FVVTEGAEEW EDDEKLPQVA PGEVLKVPGS
     VVSFVERLDD ELIRSLQHID PHTAEYIERL GDEQLLYNNI VRVLLYVEGL NQVEKSEPRQ
     DSVNRVLMRR LEHLYFKPSQ VVTILEDNTW KDLPEKLSSS ITPRDMKSDV SLLVQTICNY
     LFQYSDGIIR ARAMLCQIYF LALHDKYHRA RDLMLMSHLT ENISNFDVST QILFNRTLVQ
     IGLCAFRAGL IYEAQNTLSE VCGSGRQKEL LAQGIILQRY SSVSPEQEKL ERQRQLPFHM
     HINLELLECI YLTSSMFLEV PLMAQTSSSP EMKRRIISKT FRRMLDYNER QVFTGPPENT
     RDGVIMSAKF LAAGDWKKAS ETLNSIKIWD LMAQPDKIKA MLAQQIQEEG LRTYLFTYAP
     FYDTLSITTL SNMFDLTEKK ISAIISRMIS HEELAAALDQ VNNAIVFRKG VELSRLQSQI
     VTLADKSMSL LEANEKTLEQ RTQGMANAFQ RDQGPGGRLG RGQGRGGQRT AGGRPPIGGQ
     QRRPGGQQFS GGALGGAIKA