ID   EIF3C_CRYNB             Reviewed;         885 AA.
AC   P0CN47; Q55ST7; Q5KH72;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE            Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE   AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE            Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE   AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN   Name=NIP1 {ECO:0000255|HAMAP-Rule:MF_03002}; OrderedLocusNames=CNBE0970;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC       Rule:MF_03002}.
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DR   EMBL; AAEY01000024; EAL20734.1; -; Genomic_DNA.
DR   RefSeq; XP_775381.1; XM_770288.1.
DR   AlphaFoldDB; P0CN47; -.
DR   SMR; P0CN47; -.
DR   EnsemblFungi; AAW43537; AAW43537; CNE01020.
DR   EnsemblFungi; EAL20734; EAL20734; CNBE0970.
DR   GeneID; 4936102; -.
DR   KEGG; cnb:CNBE0970; -.
DR   VEuPathDB; FungiDB:CNBE0970; -.
DR   HOGENOM; CLU_004304_0_2_1; -.
DR   Proteomes; UP000001435; Chromosome 5.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_03002; eIF3c; 1.
DR   InterPro; IPR027516; EIF3C.
DR   InterPro; IPR008905; EIF3C_N_dom.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13937; PTHR13937; 1.
DR   Pfam; PF05470; eIF-3c_N; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..885
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   C"
FT                   /id="PRO_0000410077"
FT   DOMAIN          624..797
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          822..885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..75
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   885 AA;  98766 MW;  69EAB22BB5758D7F CRC64;
     MSFFAKLQGS DSESSSGSES EESILSGSEG ERQDKKLAAQ KKQQKSKASM FLNSEESESE
     EESSDEDEEE MSDSDDERQA VANKFLNDAA SSDEESEEED KIIVLSAKDK RFAEMEAAIH
     SIQNAVKNTD WVLASSELDK LFRFIARHLV TIVASPIPAE GHIPPRFLET LVSLEADVAK
     TLAAEKSAPK KMAPAKAKAV NGIRQTLKKK SKEFDGVLKT YNEDPEAYTA AYEKANAAPA
     APKPKKAAVT TPGEGEDDEF MTIGKGGKTL NLTADGVFKT LREIFEARGR KNTDRAETIK
     ILTKLLEVSE TTYQKIRVLL ALVPARLDYS QHLVSIPQES WVTALQEFDQ LISILIAEPD
     YLVQETVGEY DDLVERTPEV VDGKKQKVLI AGSLISLLES LDSELTKTLQ HTDAHEKGDE
     YIDRLKHEAP LYTTIVKAQT LFEREQLSDN IARTVIRRLE HIYAKPDIII EHFESKATQA
     AAGLKSEITP FDVKRDASGV IHDLAVFIYQ SDAPVLRARA ILYHIFNQAL HGRYHQARDL
     LLMSHLQDTI SHADVTTQIL YNRAVMQVGL AAFRLGFIPE CQTILSEMFS TLRQKELLAQ
     SVQRYNIQLS PEQELLEKRR LLPFHMHLNV ELLEAAYLTS CMLVEIPLLA SVDTEEQRRR
     VTSKTFKRLL DMADRQAFMG PPENTRDHII KASQALQAGE WEKARDLIVS IKVWSLLDNA
     AEVKDILAKK IQEEGLRTSL FTYAAYYDSL SLSHLASTFN LPVGRITSII SRMIYTDELA
     ASLDQIDGVV IFHRVEQSEV QRLAQQLAER TASMLEQNEK TLDVKLGNQG QGQDRDTRAV
     GGEGGRQQGE RRGGRGTYRG RGGRGGRGGF NQGLGTTMGR RVTAQ