EIF3C_CRYNJ
ID EIF3C_CRYNJ Reviewed; 885 AA.
AC P0CN46; Q55ST7; Q5KH72;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=NIP1 {ECO:0000255|HAMAP-Rule:MF_03002}; OrderedLocusNames=CNE01020;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; AE017345; AAW43537.1; -; Genomic_DNA.
DR RefSeq; XP_570844.1; XM_570844.1.
DR AlphaFoldDB; P0CN46; -.
DR SMR; P0CN46; -.
DR STRING; 5207.AAW43537; -.
DR PaxDb; P0CN46; -.
DR PRIDE; P0CN46; -.
DR EnsemblFungi; AAW43537; AAW43537; CNE01020.
DR GeneID; 3257622; -.
DR KEGG; cne:CNE01020; -.
DR VEuPathDB; FungiDB:CNE01020; -.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_2_1; -.
DR InParanoid; P0CN46; -.
DR OMA; VVMHRSE; -.
DR OrthoDB; 273138at2759; -.
DR Proteomes; UP000002149; Chromosome 5.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..885
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000366881"
FT DOMAIN 624..797
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..75
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 885 AA; 98766 MW; 69EAB22BB5758D7F CRC64;
MSFFAKLQGS DSESSSGSES EESILSGSEG ERQDKKLAAQ KKQQKSKASM FLNSEESESE
EESSDEDEEE MSDSDDERQA VANKFLNDAA SSDEESEEED KIIVLSAKDK RFAEMEAAIH
SIQNAVKNTD WVLASSELDK LFRFIARHLV TIVASPIPAE GHIPPRFLET LVSLEADVAK
TLAAEKSAPK KMAPAKAKAV NGIRQTLKKK SKEFDGVLKT YNEDPEAYTA AYEKANAAPA
APKPKKAAVT TPGEGEDDEF MTIGKGGKTL NLTADGVFKT LREIFEARGR KNTDRAETIK
ILTKLLEVSE TTYQKIRVLL ALVPARLDYS QHLVSIPQES WVTALQEFDQ LISILIAEPD
YLVQETVGEY DDLVERTPEV VDGKKQKVLI AGSLISLLES LDSELTKTLQ HTDAHEKGDE
YIDRLKHEAP LYTTIVKAQT LFEREQLSDN IARTVIRRLE HIYAKPDIII EHFESKATQA
AAGLKSEITP FDVKRDASGV IHDLAVFIYQ SDAPVLRARA ILYHIFNQAL HGRYHQARDL
LLMSHLQDTI SHADVTTQIL YNRAVMQVGL AAFRLGFIPE CQTILSEMFS TLRQKELLAQ
SVQRYNIQLS PEQELLEKRR LLPFHMHLNV ELLEAAYLTS CMLVEIPLLA SVDTEEQRRR
VTSKTFKRLL DMADRQAFMG PPENTRDHII KASQALQAGE WEKARDLIVS IKVWSLLDNA
AEVKDILAKK IQEEGLRTSL FTYAAYYDSL SLSHLASTFN LPVGRITSII SRMIYTDELA
ASLDQIDGVV IFHRVEQSEV QRLAQQLAER TASMLEQNEK TLDVKLGNQG QGQDRDTRAV
GGEGGRQQGE RRGGRGTYRG RGGRGGRGGF NQGLGTTMGR RVTAQ
