EIF3C_CULQU
ID EIF3C_CULQU Reviewed; 904 AA.
AC B0W0S3;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=eIF3-S8 {ECO:0000255|HAMAP-Rule:MF_03002}; ORFNames=CPIJ000742;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; DS231818; EDS41375.1; -; Genomic_DNA.
DR RefSeq; XP_001842307.1; XM_001842255.1.
DR AlphaFoldDB; B0W0S3; -.
DR SMR; B0W0S3; -.
DR STRING; 7176.CPIJ000742-PA; -.
DR GeneID; 6031517; -.
DR KEGG; cqu:CpipJ_CPIJ000742; -.
DR VEuPathDB; VectorBase:CPIJ000742; -.
DR VEuPathDB; VectorBase:CQUJHB010886; -.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_0_1; -.
DR InParanoid; B0W0S3; -.
DR OMA; VVMHRSE; -.
DR OrthoDB; 273138at2759; -.
DR PhylomeDB; B0W0S3; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 2.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..904
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000365384"
FT DOMAIN 636..812
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..182
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..229
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 105521 MW; C9D18A195709DB1A CRC64;
MSRFFAGGSE SDSDSSSDSE PIQRQTAPQF TFSDEEEDVK RVVRSTKEKR YEDLSNIIKS
IRNYKKIKDM SSLLSSFEDL TRAYAKALPV ITKEENGVCP RFIIRALAEL EDFINEVWDD
REGRKNLSKN NSKSLGALRQ KFRKYIKDFD SDLKKFRESP DAADDEDEEE EKKEEEESDD
EEAAVVPAAK AVSFKKDTVE KVKVEKDDDD SDDSIDWGQD SDSDESSSEE EAYGANIRER
FLKRPEKEDG DDGEKKKEKK KTKETKDSRK KKRVEDDDDE GWESSATSEK PKMFAKDAEI
DVALVVNKLN EVMAARGKKR TDRKLQIEFL RELRAISEEK KLGAAVAAKI RFNIVSAIFD
YNPKVSEPMK LEHWSKLLEE IQALIKLLLA NEDIVLSENI LDENEEYDTA PYKIRGCMLT
AVERLDDEFT KLLKECDPHS NEYVDRLKDE VTVTNVIEQV VQYVERLGNE METCRIYLRK
IDHLYYKFDP NVLKKRKAQL PASSLTSVDE MERLCRFIYA KDQTDRLRTR AILSHIFHHA
LHDNWFQARD LVLMSHLQET IHHSDPPTQI LYNRTMANLG LCAFRHGNIK DAHQCLVDLM
MTGKPKELLA QGLVPQRQNE RSLEQEKVEK QRQMPFHMHI NLELLECVYL VSAMLLEIPY
MAAHEFDARR RMISKTFYQQ LRSSERQSLV GPPESMREHV VAAAKAMRHG DWQACSNFIV
NKKMNVKVWD LFYEADRVRE MLAKFIKEEA LRTYLFTYSN VYASISVPYL AEMFDLPKSK
VHSLISKMII NEELMASLDD PTETVVLHRS EPSRLQALSM QLADKVTNLV DSNERVFEMK
QGNFFQRGGN QGYNRDRQNY RNQNQNRENW NNNRRQDRGN RNRNQNRDRE QREQHRVEFE
EKAE
