EIF3C_DEBHA
ID EIF3C_DEBHA Reviewed; 852 AA.
AC Q6BJF7;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=NIP1 {ECO:0000255|HAMAP-Rule:MF_03002};
GN OrderedLocusNames=DEHA2G02750g; ORFNames=DEHA0G03234g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; CR382139; CAG90112.1; -; Genomic_DNA.
DR RefSeq; XP_461664.1; XM_461664.1.
DR AlphaFoldDB; Q6BJF7; -.
DR SMR; Q6BJF7; -.
DR STRING; 4959.XP_461664.1; -.
DR EnsemblFungi; CAG90112; CAG90112; DEHA2G02750g.
DR GeneID; 2904530; -.
DR KEGG; dha:DEHA2G02750g; -.
DR VEuPathDB; FungiDB:DEHA2G02750g; -.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_2_1; -.
DR InParanoid; Q6BJF7; -.
DR OMA; VVMHRSE; -.
DR OrthoDB; 273138at2759; -.
DR Proteomes; UP000000599; Chromosome G.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 2.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..852
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000364282"
FT DOMAIN 597..772
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..54
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 96431 MW; 78901D0FB1FBC33A CRC64;
MSRFFVSGYP SDSSSEEEDL LSSSEEELLS SESEEDNFSS DSEFGNDSDN DSSDSDSDGA
PSGPTYFLKK DFMKGSGDGS DSDSDDEGRK VVKSAKDKLL DDMRDSIESI NTAKRVGNWT
NILAEFEKLG RLLIKVGQQK IGTPNFYVKC LANLEDYINE TVTNEKESTK KMNATYSRAF
NTVRQRVKKQ IKEYQSHMDL FRTKPELFET EEPLEGIAST IAGAPQLNGD EDSNAFTSVG
AKTFSPIFTT LKQISETRGK KNIDKVEQIQ TLEDLLNDTS STGTPFELIS IYQMLLSIRF
DASSNQSFMP IDQWKKNEAD LNSFLQLLKS KSKEYQVSEL GTVTDDIDIE PPANADGVKV
VFGSIASLIE RLDDEFTRSL QYSDPHSIEY IQRLKDESII YKLIVKGQLY VESTTPVEIR
SKHEAGQLFR IVMRRLEHIH YKPNQLIAAN ETEAWKNIDT NVDSTIVPRN SDPNDLVVGL
ADFLTQNAKS IYGKNALLCS IYYYAINNQY VKARDLFLSS HIYSTIHNSE SSLQVMYNRA
LVQLGLSAFK AGVIEESHQA LNEIANSQRL KELLGQGFNS KYPSQATTAE KQKLLPFHMH
INLELLECVF MTSSLLIEIP AMAAVSSSSK DSKRKASLKS FKSKLDFHER QYFTGPPESI
KDHVVHSSIA LQKGDWAKAY KLLSSIKIWK LIPDNEQLLS MMKKQLQVEG LRTYIFTYKS
IYTKLSIAKL SAIFDIEKES VYSIIDKMIQ PGDISGSIDE SKSFVNFTTN DHQRTKLQEL
AIVMNEKVGL LTEKNEKTAS NGYSRKQPMQ QQQQQQQQQQ QQKEQKELLH EENNRFRYAN
VNANNDEFQT TA
