EIF3C_DICDI
ID EIF3C_DICDI Reviewed; 936 AA.
AC Q54X97;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=eif3C; Synonyms=eif3s8; ORFNames=DDB_G0279109;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; AAFI02000027; EAL67893.1; -; Genomic_DNA.
DR RefSeq; XP_641870.1; XM_636778.1.
DR AlphaFoldDB; Q54X97; -.
DR SMR; Q54X97; -.
DR STRING; 44689.DDB0233926; -.
DR PaxDb; Q54X97; -.
DR EnsemblProtists; EAL67893; EAL67893; DDB_G0279109.
DR GeneID; 8621876; -.
DR KEGG; ddi:DDB_G0279109; -.
DR dictyBase; DDB_G0279109; eif3C.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_2_1; -.
DR InParanoid; Q54X97; -.
DR OMA; VVMHRSE; -.
DR PhylomeDB; Q54X97; -.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DDI-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DDI-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:Q54X97; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:dictyBase.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:dictyBase.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..936
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000330330"
FT DOMAIN 643..814
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..187
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..258
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..882
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 106690 MW; 9E15FC9BFC89F9BC CRC64;
MSRFYRQGSS SESSSESSSD SDVQVKKPTR YVSSSEDEIE EKRIVLSAKD KIWQQFDESL
KKVRNALKTN DWVSTTSEFD NMTKLITNGK TTRIIEKEGF PPSFIKALFI IQTSHRDLTT
EQKKKLHANN NKSYNSIKQK LKKTCDLYAK ELKPYHDNPA LVNEQENKAN SDDDDDDLSE
SESEESESSD DDKGKGKGKA AFGKKPATKA VVAKKPLTKK GDDDSESESE ESESESEELI
SESWSSDSDD DSDSDSDDDS GDNKWMIKDD KKVVAKASVT TVRKTDKDKL DRRNAVVSPL
SGSGSAVPTA GEGEGEKLTQ DQIMKKVKEV ISNRGKLKTD PMKQIQQLEY FYSLIQGDKE
TFIVLYELIA AQFDTASVKV ALSIPVWQKV ADGIKKLLEI LETNTNFVLV LEHQEPTISK
GQVAVTGNLL ALFEMLDDEF SKSLQSINYP TKEYLDRLQD EQIILDLGES LQKYYESAGN
NGAAAKIAIR RIEHIYYKSS NLKNNIIPST MPLSEQITLM SKLSSFVYKF GDERLNARTI
LCNIYFNAIN NKFHEARDMM LMSHLQDNPT LMDVSTQILF NRAMVQLGLC AFRCGYIQEA
QNCVVEFSGL RKDLLAQGLS VQSKTAEKDT VREVEETTRI LPAHMWIPID LIETVNLISG
MLIAVPQNAY RPFDNKFKTC KFYQRHMDSV DRQIFIAPSE TSKDIIYQAS KALSAGDWQQ
CLEHVNTLRF WSLIPDIDSV REKLTRIVQE VSLKTFLFTY STSYDSILLS ELADRFHLPK
SQVHSIVAKM MNNHEISASM EHSTESITFR AEQTKLQYLA LHYSESLVDF VEQNERIYDV
KFGTSYRKKG DNDHLPIAGG QHHGHQHHGH QHHGHHHHNQ QQQQHHQQQQ QTTQHHHHHH
QNQNQGNQQY QNKKHHNSNQ QKSHKKRQNN SLVVNN
