EIF3C_PHANO
ID EIF3C_PHANO Reviewed; 853 AA.
AC Q0V1H5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=NIP1 {ECO:0000255|HAMAP-Rule:MF_03002}; ORFNames=SNOG_02139;
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; CH445327; EAT90351.1; -; Genomic_DNA.
DR RefSeq; XP_001792757.1; XM_001792705.1.
DR AlphaFoldDB; Q0V1H5; -.
DR SMR; Q0V1H5; -.
DR STRING; 13684.SNOT_02139; -.
DR EnsemblFungi; SNOT_02139; SNOT_02139; SNOG_02139.
DR GeneID; 5969607; -.
DR KEGG; pno:SNOG_02139; -.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_2_1; -.
DR InParanoid; Q0V1H5; -.
DR OMA; VVMHRSE; -.
DR OrthoDB; 273138at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..853
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000364288"
FT DOMAIN 599..773
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..47
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 96545 MW; 1708260950DAFE2D CRC64;
MSRFFAASDS SSEESSEEEL YSDNEASAQE DSDKDSDDDD SDDDDSSSGS EAGGANRFLK
DADSDSESED EDQNKVLKSA KDKRFDELEA TIRLIENAQR INDWAVISDQ FDKLNRQAPT
LMKQNDGKVP KLYIQAIADL ETVVLETHEK QKVTPKKMNA VNTRGFNAVR QKVKKHNREF
QKDIDLYREN KDEFMRETEE VEAAPKEKKK KSKIPQLGTE IVDEATDDGF ITVGAGGKAV
QYTPEGILKH LRAIVEQRGR KNSDKLEHIR TLEKLFDVSV NDYQRIRVLL TLISTRFDLT
SGTASHMHQD QWKLADQEFG KLLEILENTK EIVVIENAEE WEDDDKLPPI EEGQIFRIPG
SVVSFVERLD DELTRSLQHI DPHTAEYVER LTDEALLYAQ LVRALIYVES LKKNASLELP
QESLNRVVMR RLEHVYFKPS QVVTIMEANS WKAVPETLDS EVTPRAISND TTSLVQTLST
YLFQNSEGII RARAMLCQIY FLALHDQYYK ARDMMLMSHL QETISNFDVN TQILFNRALV
QVGLCAFRAG LVYESQNSLQ EICGSNRQKE LLAQGLQMQR YSQISPEQER LERQRQLPFH
MHINLELLEC VYLTCSMLLE IPLLAQLGSS PDLRKRVISK TYRRLLEYHE RQIFTGPPEN
TRDHVMQASK ALSAGEWKKA AEFINSIKIW ELVADSEKIK EMLSAQIQEE GLRTYLFTYA
PYYDTLAVST LASMFELSER KVSAVVSKMI SHEELAAALD QVNSAIIFRK GVELSRLQTL
ALSLSDKASG LIESNEKTLE QRTQGTANAF ERQGGRGGRG GGRGRGGGRG GGVPRGGRNQ
QFTGGALGRA IQA
