EIF3C_XENTR
ID EIF3C_XENTR Reviewed; 922 AA.
AC Q6P1V4;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=eif3c; Synonyms=eif3s8; ORFNames=TGas102o09.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC eif3m. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; CR942354; CAJ83565.1; -; mRNA.
DR EMBL; BC064857; AAH64857.1; -; mRNA.
DR RefSeq; NP_989413.1; NM_204082.2.
DR AlphaFoldDB; Q6P1V4; -.
DR SMR; Q6P1V4; -.
DR PaxDb; Q6P1V4; -.
DR Ensembl; ENSXETT00000006431; ENSXETP00000006431; ENSXETG00000002941.
DR GeneID; 395052; -.
DR KEGG; xtr:395052; -.
DR CTD; 8663; -.
DR Xenbase; XB-GENE-5720067; eif3c.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_004304_0_0_1; -.
DR InParanoid; Q6P1V4; -.
DR OMA; VVMHRSE; -.
DR OrthoDB; 273138at2759; -.
DR PhylomeDB; Q6P1V4; -.
DR TreeFam; TF101520; -.
DR Reactome; R-XTR-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-XTR-72649; Translation initiation complex formation.
DR Reactome; R-XTR-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-XTR-72702; Ribosomal scanning and start codon recognition.
DR Proteomes; UP000008143; Chromosome 9.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000002941; Expressed in neurula embryo and 22 other tissues.
DR ExpressionAtlas; Q6P1V4; baseline.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 2.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..922
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000365379"
FT DOMAIN 674..850
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..185
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..242
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..911
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 106480 MW; 3F0970B2A6F2B002 CRC64;
MSRFFATGSD SESESSLSGD EILPKPVGGT FGKQPIILSD DEEDTKRVVR SAKDKRFEEL
TNLIKTIRNA MKIRDMTKCL EEFEQLGKAF IKAKNIVDKE GVPRFYIRLL SDLEDYLNEL
WEDKEGKKKM NKNNAKALST LRQKLRKYNR DFEAPIAAYK QNPEESADED QEKDEDSEAS
SSSDDDSDEG MSASKFLKKA DSAPPESRSK FLKKEEAEDE ESSSDDEDWG SDSDESDSDE
SDDENKYTSM ASRFLKKTVN EGDRQAAEKK KEEKAKKKQH RKVKRKDEEG EEEEDDNEGG
GEWEKVKGGV PLVKEKPKMF AKGTEITPPI VVKKLNEILQ ARGKKGTDRA AQIDLLHLLA
GIAEENNLGQ GIAVKIKFNI VASLYDYNTN LATYMKADMW KKCLDSIHDL LDILFANSNM
FIGEHISEDS ENLSNTDQPL RVRGCILTLI ERMDEEFTKI MQNTDPHSQE YVDNLKDEAR
VCEVIERAQK YLQEKGSTEE VCRVYLRRIM HTYYKFDYKA HQRQLSTGQE SKSEQDQAEN
EAEDSAILMD RLCKYIYAKD RTDRIRTCAI LCHIYHHALH NRWFQARDLM LMSHLQDNIQ
HADPPVQILY NRTMVQLGIC AFRQGMIRDA HNALLDIQSS GRAKELLGQG LLMRTMQERN
QEQEKIEKRR QIPFHMHINL ELLECVYLVS AMLLEIPYMA AHEFDARRRM ISKQFHHQLR
VGERQPLLGP PESMREHVVA ASKAMKMGDW KTCKNFIINE KMNGKVWDLF PEAERVRSML
IRKIQEESLR TYLFTYSSVY DSIRMGILGD MFQLEIPTVH SIISKMIINE ELMASLDQPT
QTVVMHGTEP SSLQNTALQL AEKLGNLVEN NERIFDHKQG SYGGYFNRGD RGDRDQKDQY
QRKEGGYMRR GYRRDQQGQS NY
