EIF3C_YARLI
ID EIF3C_YARLI Reviewed; 826 AA.
AC Q6C855;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3c {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
DE Short=eIF3 p93 {ECO:0000255|HAMAP-Rule:MF_03002};
DE AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000255|HAMAP-Rule:MF_03002};
GN Name=NIP1 {ECO:0000255|HAMAP-Rule:MF_03002};
GN OrderedLocusNames=YALI0D22572g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit C family. {ECO:0000255|HAMAP-
CC Rule:MF_03002}.
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DR EMBL; CR382130; CAG81355.1; -; Genomic_DNA.
DR RefSeq; XP_503157.1; XM_503157.1.
DR AlphaFoldDB; Q6C855; -.
DR SMR; Q6C855; -.
DR STRING; 4952.CAG81355; -.
DR EnsemblFungi; CAG81355; CAG81355; YALI0_D22572g.
DR GeneID; 2910336; -.
DR KEGG; yli:YALI0D22572g; -.
DR VEuPathDB; FungiDB:YALI0_D22572g; -.
DR HOGENOM; CLU_004304_0_2_1; -.
DR InParanoid; Q6C855; -.
DR OMA; VVMHRSE; -.
DR Proteomes; UP000001300; Chromosome D.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_03002; eIF3c; 1.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13937; PTHR13937; 1.
DR Pfam; PF05470; eIF-3c_N; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..826
FT /note="Eukaryotic translation initiation factor 3 subunit
FT C"
FT /id="PRO_0000364291"
FT DOMAIN 605..779
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..65
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 92693 MW; FD989525681AD739 CRC64;
MSRFFAGGSD SDDSSSDEDL YGSGSESGSD FSQDEQDGGD DNDDDMSDDS MFADDSDDDS
DDDEDLGGKG ASYFLKSSTV ADSDDEEDTG KKTVLSAKDK LLAELANCSK LIDNGKRIND
WVLIQGEFDK LNKAMERFTK QRHGLPPKVY IQCIVELEEF LNTQLEDKAG IKKMNASNSR
AFNTVKQRVR KNNKEYEAAI AKYSSGGDVA EEEEEENKED KPKPRAKDEF VLTAPSQASN
EEFTTVGKAG KALVSPTDMF KTLKTVLESR GKKNTDREDQ VRQLENLLPS ASTVYQKISV
YTMLVSTRLD LSSASAALAP ENWLKVVGDL NDLLSILEEN IDTYHVIETA PEIEDVEKGP
VAREDGVKLI PGSVASLVER VDDEFTKALQ FMDPHTTEYV DRLRDETKLY QTLLRVQMYI
EHVSDEKDTL GLARILVRRV DHLYFKPNNV INMTEQIAWG GVKGDSKATP RPTEKDLTSS
TYPTTLISNM CSVLYKQSNT VFRTKAMLAH VYHYALNDEY YKARDMFLMS HLQSSIASAE
PQLQVLFNRT LVQLGLCAFR SGLIAEAQQS LQEVCSSPRL KELLGQGLAK YAQAGVVDKQ
RVLPFHTHIN LELLECVFLC SSLLMEIPFM AAHNTSIDAK KKVISKLFRR MLDYHERQVF
CGPPENTRDH IMQAAKALQR GDWEAARDLV CAIKIWSLLP NPEAIKAMLT DKLQIEGLRT
YLFTYWNHYS TLSLSTLADM FQLPVKDVAA IVAKMIAQEE LPGSLDQKTN SVVFTQAVQQ
TKLQQLAVAL SDKVIQLAER NERLVAGGYQ FDKMTQPQKR KTQRAR
