ID   EIF3D_CAEBR             Reviewed;         574 AA.
AC   A8X371;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit D {ECO:0000255|HAMAP-Rule:MF_03003};
DE            Short=eIF3d {ECO:0000255|HAMAP-Rule:MF_03003};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 7 {ECO:0000255|HAMAP-Rule:MF_03003};
GN   Name=eif-3.D {ECO:0000255|HAMAP-Rule:MF_03003,
GN   ECO:0000312|WormBase:CBG06842};
GN   ORFNames=CBG06842 {ECO:0000312|WormBase:CBG06842};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. In the
CC       eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC       methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP-
CC       Rule:MF_03003}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC       promiscuous mRNA-binding before assembly of eif3d into the full
CC       eukaryotic translation initiation factor 3 (eIF-3) complex.
CC       {ECO:0000255|HAMAP-Rule:MF_03003}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-
CC       Rule:MF_03003}.
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DR   EMBL; HE601347; CAP27081.1; -; Genomic_DNA.
DR   RefSeq; XP_002642438.1; XM_002642392.1.
DR   AlphaFoldDB; A8X371; -.
DR   SMR; A8X371; -.
DR   STRING; 6238.CBG06842; -.
DR   EnsemblMetazoa; CBG06842.1; CBG06842.1; WBGene00029048.
DR   GeneID; 8584432; -.
DR   KEGG; cbr:CBG_06842; -.
DR   CTD; 8584432; -.
DR   WormBase; CBG06842; CBP07485; WBGene00029048; Cbr-eif-3.D.
DR   eggNOG; KOG2479; Eukaryota.
DR   HOGENOM; CLU_024521_2_1_1; -.
DR   InParanoid; A8X371; -.
DR   OMA; PDGWGPC; -.
DR   OrthoDB; 1030308at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0098808; F:mRNA cap binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0002191; P:cap-dependent translational initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   HAMAP; MF_03003; eIF3d; 1.
DR   InterPro; IPR007783; eIF3d.
DR   PANTHER; PTHR12399; PTHR12399; 1.
DR   Pfam; PF05091; eIF-3_zeta; 1.
DR   PIRSF; PIRSF016281; EIF-3_zeta; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..574
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   D"
FT                   /id="PRO_0000364137"
FT   REGION          153..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..326
FT                   /note="RNA gate"
FT                   /evidence="ECO:0000250|UniProtKB:K7IM66"
FT   REGION          555..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  64776 MW;  0B665372BD434D64 CRC64;
     MATTELPKFE LLSLADNTSG WGPLTTSSSS VEPVPFQQFN KADRIGRVAD WIGVDRFFRR
     GNERYNERVY GSAANAGSQF DYIHGMDEHN FQLVDTSKPM ARNPQRNFRV RQMHLRKMMQ
     KEVEKREMVN QTTNLRMKRS IAKEQQRAFK MWQRRGGNAR QGQRGQGGRF GGDRPKERLP
     SVQVRPEWGV LEEMNLSAFS KLALPNIPGG EDIGDHQYGS LQYYDKTVDR VSVKNSVPLQ
     RCAGVYYNVT TTEDPVIQEL AQGGVGNVFG TDIILATLMT APRSVYSWDI VAYRIGDKLF
     FDKRNTKDIL NPVETLTVSE TSAEPPSFDG NGLNNARDLA TEAFYINQNF RRQVVKRNEP
     GFTFKNVRVP FEDEETGDAT GTAYKYRKWN LGNGVDGKPV ELVCRTELDG VIHGLGNETQ
     TLTIKAFNEW DSSQAGGVDW RTKLDVQKGA VMATEIKNNS AKVAKWTLQA LLAGSDTMKL
     GYVSRNNARS TQNHSILNTQ YVKPTEFASN IALNMDNCWG ILRCVIDSCM KQKPGKYLLM
     KDPQSPVIRL YSLPEGTFDS ERESSEEENS DDDQ