EIF3D_CAEEL
ID EIF3D_CAEEL Reviewed; 570 AA.
AC P30642;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit D {ECO:0000255|HAMAP-Rule:MF_03003};
DE Short=eIF3d {ECO:0000255|HAMAP-Rule:MF_03003};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 7 {ECO:0000255|HAMAP-Rule:MF_03003};
GN Name=eif-3.D {ECO:0000255|HAMAP-Rule:MF_03003}; ORFNames=R08D7.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation. In the
CC eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP-
CC Rule:MF_03003}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- INTERACTION:
CC P30642; G5EGG0: uso-1; NbExp=2; IntAct=EBI-311981, EBI-311986;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC promiscuous mRNA-binding before assembly of eif3d into the full
CC eukaryotic translation initiation factor 3 (eIF-3) complex.
CC {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-
CC Rule:MF_03003}.
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DR EMBL; Z12017; CAA78049.1; -; Genomic_DNA.
DR PIR; S41038; S24459.
DR RefSeq; NP_498984.1; NM_066583.4.
DR AlphaFoldDB; P30642; -.
DR SMR; P30642; -.
DR BioGRID; 41467; 28.
DR DIP; DIP-25819N; -.
DR IntAct; P30642; 13.
DR STRING; 6239.R08D7.3; -.
DR iPTMnet; P30642; -.
DR EPD; P30642; -.
DR PaxDb; P30642; -.
DR PeptideAtlas; P30642; -.
DR PRIDE; P30642; -.
DR EnsemblMetazoa; R08D7.3.1; R08D7.3.1; WBGene00001227.
DR GeneID; 176268; -.
DR KEGG; cel:CELE_R08D7.3; -.
DR CTD; 176268; -.
DR WormBase; R08D7.3; CE00291; WBGene00001227; eif-3.D.
DR eggNOG; KOG2479; Eukaryota.
DR GeneTree; ENSGT00390000002667; -.
DR HOGENOM; CLU_024521_2_1_1; -.
DR InParanoid; P30642; -.
DR OMA; PDGWGPC; -.
DR OrthoDB; 1030308at2759; -.
DR PhylomeDB; P30642; -.
DR Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:P30642; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00001227; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:WormBase.
DR GO; GO:0098808; F:mRNA cap binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0002191; P:cap-dependent translational initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; ISS:WormBase.
DR HAMAP; MF_03003; eIF3d; 1.
DR InterPro; IPR007783; eIF3d.
DR PANTHER; PTHR12399; PTHR12399; 1.
DR Pfam; PF05091; eIF-3_zeta; 1.
DR PIRSF; PIRSF016281; EIF-3_zeta; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW RNA-binding.
FT CHAIN 1..570
FT /note="Eukaryotic translation initiation factor 3 subunit
FT D"
FT /id="PRO_0000123523"
FT REGION 150..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..323
FT /note="RNA gate"
FT /evidence="ECO:0000250|UniProtKB:K7IM66"
FT REGION 551..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 64289 MW; D1DC35E2796BA362 CRC64;
MALPKFELLS LADNTVGWGP LASSSSADEP VPFQQFNKAD RIGRVADWIG VDRFYRRGNE
RYNERVYGSA ANAGSQFDYI HGMDEHNFQL VDTSKPMARN PQRNFRVRQM HLRKMMQKEN
EKREMVNQST NLRMKRSIAK EQQRAFKMWQ RRGGNARQGQ RGQGGRFGGD RPKERLPSVQ
VRPEWVVLEE MNLSAFSKLA LPNIPGGDDI GDHQYGSLQY YDKTIDRVSV KNSIPLQRCA
GVFYNVTTTE DPVIQELAQG GAGNVFGTDI ILATLMTAPR SVYSWDIVAY RVGDKLFFDK
RNTRDILNPV ETLTVSETSA EPPSFDGNGI NNAKDLATEA FYINQNFRRQ VVKRNDAGFT
FKNARAPFED EETGESGTAY KYRKWNLGNG VDGKPVELVC RTELDGVIHG LGNETQTLTI
KAFNEWDSTQ SGGVDWRTKL DVQKGAVMAT EIKNNSAKVA KWTLQALLAG SDTMKLGYVS
RNNARSTQNH SILLTQYVKP TEFASNIALN MDNCWGILRC VIDSCMKQKP GKYLLMKDPQ
SPVIRLYSLP EGTFESERES SDEENSDDDQ
